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Limited asymptomatic carriage of Pneumocystis jiroveci in human immunodeficiency virus-infected patients

Wakefield, AE; Lindley, AR; Ambrose, HE; Denis, CM; Miller, RF; (2003) Limited asymptomatic carriage of Pneumocystis jiroveci in human immunodeficiency virus-infected patients. J INFECT DIS , 187 (6) 901 - 908. Green open access

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Abstract

Forty-seven bronchoalveolar lavage fluid samples from 16 human immunodeficiency virus (HIV)-infected patients were used to test the latency model of Pneumocystis infection in the human host. Identification of DNA sequence polymorphisms at 4 independent loci were used to genotype Pneumocystis jiroveci from the 35 samples that contained detectable P. jiroveci DNA. Eighteen of those 35 samples came from patients who did not have Pneumocystis pneumonia (PCP) and had confirmed alternative diagnoses. Seven patients had asymptomatic carriage of P. jiroveci over periods of less than or equal to9.5 months after an episode of PCP, and in all 7 cases, a change in genotype from that in the original episode of PCP was observed. The absence of P. jiroveci DNA in one-fourth of the 47 samples and the observed changes in genotype during asymptomatic carriage do not support the latency model of infection. Asymptomatic carriage in HIV-infected patients may play a role in transmission of P. jiroveci and may even supply a reservoir for future infections.

Type: Article
Title: Limited asymptomatic carriage of Pneumocystis jiroveci in human immunodeficiency virus-infected patients
Open access status: An open access version is available from UCL Discovery
Keywords: F SP. HOMINIS, DIHYDROPTEROATE SYNTHASE GENE, TRANSCRIBED SPACER REGIONS, HIV-POSITIVE PATIENTS, RIBOSOMAL-RNA GENES, CARINII-PNEUMONIA, DNA AMPLIFICATION, AIDS PATIENTS, SULFONE PROPHYLAXIS, RECURRENT PNEUMONIA
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health > Infection and Population Health
URI: https://discovery.ucl.ac.uk/id/eprint/6761
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