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SLC2A9 is a high-capacity urate transporter in humans

Caulfield, MJ; Munroe, PB; O'Neill, D; Witkowska, K; Charchar, FJ; Doblado, M; Evans, S; ... Cheeseman, C; + view all (2008) SLC2A9 is a high-capacity urate transporter in humans. PLoS Medicine , 5 (10) , Article e197. 10.1371/journal.pmed.0050197. Green open access

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Abstract

Serum uric acid levels in humans are influenced by diet, cellular breakdown, and renal elimination, and correlate with blood pressure, metabolic syndrome, diabetes, gout, and cardiovascular disease. Recent genome-wide association scans have found common genetic variants of SLC2A9 to be associated with increased serum urate level and gout. The SLC2A9 gene encodes a facilitative glucose transporter, and it has two splice variants that are highly expressed in the proximal nephron, a key site for urate handling in the kidney. We investigated whether SLC2A9 is a functional urate transporter that contributes to the longstanding association between urate and blood pressure in man.

Type: Article
Title: SLC2A9 is a high-capacity urate transporter in humans
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pmed.0050197
Publisher version: http://dx.doi.org/10.1371/journal.pmed.0050197
Language: English
Additional information: © 2008 Caulfield et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health
URI: https://discovery.ucl.ac.uk/id/eprint/61509
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