UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Effects of focal frontal lesions on response inhibition

Picton, TW; Stuss, DT; Alexander, MP; Shallice, T; Binns, MA; Gillingham, S; (2007) Effects of focal frontal lesions on response inhibition. CEREB CORTEX , 17 (4) 826 - 838. 10.1093/cercor/bhk031. Green open access

[img]
Preview
PDF
5857.pdf

Download (749kB)

Abstract

This study examined the performance of 38 normal subjects and 43 patients with focal lesions of the frontal lobes on a simple go-nogo task where the probability of the nogo stimulus was either 75% or 25%. Patients with lesions to the superior medial parts of the frontal lobes, in particular to the left superior portion of Brodmann area 6 (which includes the supplementary motor areas and the premotor areas for the right hand) had an increased number of false alarms (incorrect responses to the nogo stimulus). These results indicate that area 6 is specifically involved in the inhibition of response. Patients with lesions to the right anterior cingulate (areas 24 and 32) were slower and more variable in their reaction time. These findings could be explained by an inability to sustain stimulus-response contingencies. Lesions to the right ventrolateral prefrontal cortex (Brodmann areas 44, 45, 47) also increased the variability of response, perhaps by disrupting monitoring performance.

Type: Article
Title: Effects of focal frontal lesions on response inhibition
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/cercor/bhk031
Keywords: anterior cingulate, lesion localization, nogo paradigm, premotor cortex, supplementary motor areas, EVENT-RELATED FMRI, ANTERIOR CINGULATE CORTEX, GO/NO-GO DISCRIMINATION, POSTERIOR BRAIN-DAMAGE, PREFRONTAL CORTEX, COGNITIVE CONTROL, ERROR-DETECTION, LOBE LESIONS, PREMOTOR CORTEX, FUNCTIONAL MRI
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Institute of Cognitive Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/5857
Downloads since deposit
269Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item