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A behavioural and pharmacological evaluation of the discriminative stimulus induced by pentylenetetrazole in the pig

Carey, MP; Fry, JP; (1993) A behavioural and pharmacological evaluation of the discriminative stimulus induced by pentylenetetrazole in the pig. Psychopharmacology , 111 (2) pp. 244-250. 10.1007/BF02245531.

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Abstract

The anxiogenic nature of the interoceptive discriminative stimulus induced by pentylenetetrazole (PTZ) was investigated by examining the discriminatory behaviour of PTZ conditioned pigs during a conditioned emotional response (CER). A CER was induced in a nonoperant situation, by pairing a tone stimulus with the application of a mild, non-injurious electric shock. Subsequent presentation of the conditioned tone stimulus alone produced a generalisation to the PTZ cue. This generalisation of the conditioned emotional state (CES) to the PTZ cue was antagonised by pretreatment with diazepam (0.5 mg/kg, PO; 30 min). The PTZ stimulus was also antagonised by diazepam (0.5 mg/kg, PO; 30 min) but not by an anticonvulsant dose of ethosuximide (30 mg/kg, PO; 1-3 h), providing further confirmation of the anxiogenic nature of the PTZ cue. Our results demonstrate the validity of the PTZ discrimination paradigm in pigs as a test of anxiety.

Type: Article
Title: A behavioural and pharmacological evaluation of the discriminative stimulus induced by pentylenetetrazole in the pig
Location: GERMANY
DOI: 10.1007/BF02245531
Publisher version: http://dx.doi.org/10.1007/BF02245531
Language: English
Additional information: The final publication is available at Springer via http://dx.doi.org/10.1007/BF02245531.
Keywords: Animals, Behavior, Animal, Conditioning, Operant, Cues, Diazepam, Discrimination (Psychology), Electroshock, Emotions, Ethosuximide, Male, Pentylenetetrazole, Reinforcement Schedule, Swine
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: https://discovery.ucl.ac.uk/id/eprint/57575
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