Lee, RS;
Higgs, D;
Haddo, O;
Pringle, J;
Briggs, TW;
(2004)
Osteosarcoma associated with diamond-blackfan anaemia: a case of a child receiving growth hormone therapy.
Sarcoma
, 8
(1)
47 - 49.
10.1080/13577140410001679266.
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Abstract
Purpose: Diamond–Blackfan anaemia (DBA) is a rare pure congenital red cell aplasia, usually presenting in infancy or early childhood. The literature suggests a predisposition to haemopoietic malignancy but in addition solid tumours have been reported, with five cases of osteosarcoma described. Patient: A sixth case of a 12-year-old girl with DBA who developed an osteosarcoma of the distal femur is presented. Results: She was treated with methotrexate followed by tumour excision and distal femoral replacement. The patient is currently alive with multiple pulmonary metastases. Discussion: We discuss the association between the administration of growth hormone and future development of malignancy in patients with DBA.
Type: | Article |
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Title: | Osteosarcoma associated with diamond-blackfan anaemia: a case of a child receiving growth hormone therapy |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1080/13577140410001679266 |
Publisher version: | http://dx.doi.org/10.1080/13577140410001679266 |
Language: | English |
Additional information: | Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci |
URI: | https://discovery.ucl.ac.uk/id/eprint/36827 |
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