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Comparative expression profiling of Leishmania: modulation in gene expression between species and in different host genetic backgrounds.

Depledge, DP; Evans, KJ; Ivens, AC; Aziz, N; Maroof, A; Kaye, PM; Smith, DF; (2009) Comparative expression profiling of Leishmania: modulation in gene expression between species and in different host genetic backgrounds. PLoS Negl Trop Dis , 3 (7) , Article e476. 10.1371/journal.pntd.0000476. Green open access

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Abstract

Genome sequencing of Leishmania species that give rise to a range of disease phenotypes in the host has revealed highly conserved gene content and synteny across the genus. Only a small number of genes are differentially distributed between the three species sequenced to date, L. major, L. infantum and L. braziliensis. It is not yet known how many of these genes are expressed in the disease-promoting intracellular amastigotes of these species or whether genes conserved between the species are differentially expressed in the host.

Type: Article
Title: Comparative expression profiling of Leishmania: modulation in gene expression between species and in different host genetic backgrounds.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pntd.0000476
Publisher version: http://dx.doi.org/10.1371/journal.pntd.0000476
Language: English
Additional information: © 2009 Depledge et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: DD was supported by a pre-doctoral award from the UK BBSRC (www.bbsrc.ac.uk); KJE is funded by a C.J. Martin Postdoctoral Fellowship from the Australian NH&MRC (443030) (www.nhmrc.gov.au); comparative Leishmania genomics research in the Centre for Immunology and Infection is funded by the Wellcome Trust (grant 076355 to DFS/J. Mottram/PMK)(www.wellcome.ac.uk). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Keywords: Animals, Gene Expression Profiling, Host-Parasite Interactions, Leishmania braziliensis, Leishmania infantum, Leishmania major, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Knockout, Oligonucleotide Array Sequence Analysis, Stress, Physiological
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
URI: https://discovery.ucl.ac.uk/id/eprint/359386
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