Depledge, DP;
MacLean, LM;
Hodgkinson, MR;
Smith, BA;
Jackson, AP;
Ma, S;
Uliana, SR;
(2010)
Leishmania-specific surface antigens show sub-genus sequence variation and immune recognition.
PLoS Negl Trop Dis
, 4
(9)
, Article e829. 10.1371/journal.pntd.0000829.
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Abstract
A family of hydrophilic acylated surface (HASP) proteins, containing extensive and variant amino acid repeats, is expressed at the plasma membrane in infective extracellular (metacyclic) and intracellular (amastigote) stages of Old World Leishmania species. While HASPs are antigenic in the host and can induce protective immune responses, the biological functions of these Leishmania-specific proteins remain unresolved. Previous genome analysis has suggested that parasites of the sub-genus Leishmania (Viannia) have lost HASP genes from their genomes.
| Type: | Article |
|---|---|
| Title: | Leishmania-specific surface antigens show sub-genus sequence variation and immune recognition. |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pntd.0000829 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pntd.0000829 |
| Language: | English |
| Additional information: | © 2010 Depledge et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: DPD was supported by a pre-doctoral award from the UK BBSRC and SM by a Wellcome Prize pre-doctoral studentship (048615). This work has been partially supported by Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) and Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP). Research in the Smith lab is supported by the Wellcome Trust (programme grant 077503). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
| Keywords: | Antigens, Protozoan, Antigens, Surface, Gene Expression Profiling, Genetic Variation, Leishmania, Macrophages, Protozoan Proteins, Repetitive Sequences, Amino Acid, Sequence Homology, Amino Acid, Synteny, Trypanosomatina |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/352091 |
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