UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Leishmania-specific surface antigens show sub-genus sequence variation and immune recognition.

Depledge, DP; MacLean, LM; Hodgkinson, MR; Smith, BA; Jackson, AP; Ma, S; Uliana, SR; (2010) Leishmania-specific surface antigens show sub-genus sequence variation and immune recognition. PLoS Negl Trop Dis , 4 (9) , Article e829. 10.1371/journal.pntd.0000829. Green open access

[img]
Preview
PDF
352091.pdf

Download (2MB)

Abstract

A family of hydrophilic acylated surface (HASP) proteins, containing extensive and variant amino acid repeats, is expressed at the plasma membrane in infective extracellular (metacyclic) and intracellular (amastigote) stages of Old World Leishmania species. While HASPs are antigenic in the host and can induce protective immune responses, the biological functions of these Leishmania-specific proteins remain unresolved. Previous genome analysis has suggested that parasites of the sub-genus Leishmania (Viannia) have lost HASP genes from their genomes.

Type: Article
Title: Leishmania-specific surface antigens show sub-genus sequence variation and immune recognition.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pntd.0000829
Publisher version: http://dx.doi.org/10.1371/journal.pntd.0000829
Language: English
Additional information: © 2010 Depledge et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: DPD was supported by a pre-doctoral award from the UK BBSRC and SM by a Wellcome Prize pre-doctoral studentship (048615). This work has been partially supported by Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) and Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP). Research in the Smith lab is supported by the Wellcome Trust (programme grant 077503). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Keywords: Antigens, Protozoan, Antigens, Surface, Gene Expression Profiling, Genetic Variation, Leishmania, Macrophages, Protozoan Proteins, Repetitive Sequences, Amino Acid, Sequence Homology, Amino Acid, Synteny, Trypanosomatina
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
URI: https://discovery.ucl.ac.uk/id/eprint/352091
Downloads since deposit
208Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item