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SWITCHING OFF ANGIOGENIC SIGNALLING: CREATING CHANNELLED CONSTRUCTS FOR ADEQUATE OXYGEN DELIVERY IN TISSUE ENGINEERED CONSTRUCTS

Cheema, U; Alekseeva, T; Abou-Neel, EA; Brown, RA; (2010) SWITCHING OFF ANGIOGENIC SIGNALLING: CREATING CHANNELLED CONSTRUCTS FOR ADEQUATE OXYGEN DELIVERY IN TISSUE ENGINEERED CONSTRUCTS. EUR CELLS MATER , 20 274 - 281. Green open access

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Abstract

A major question in biomimetic tissue engineering is how much of the structure/function of native vasculature needs to be reproduced for effective tissue perfusion. O-2 supplied to cells in 3D scaffolds in vitro is initially dependent upon diffusion through the scaffold and cell consumption. Low O-2 (3%) enhances specific cell behaviours, but where O-2 is critically low (pathological hypoxia) cell survival becomes compromised. We measured real-time O-2 in 3D scaffolds and introduced micro-channelled architecture to controllably increase delivery of O-2 to cells and switch off the hypoxic response. Simple static micro-channelling gives adequate perfusion and can be used to control cell generated hypoxia-induced signalling.

Type: Article
Title: SWITCHING OFF ANGIOGENIC SIGNALLING: CREATING CHANNELLED CONSTRUCTS FOR ADEQUATE OXYGEN DELIVERY IN TISSUE ENGINEERED CONSTRUCTS
Open access status: An open access version is available from UCL Discovery
Publisher version: http://www.ecmjournal.org/journal/papers/vol020/vo...
Language: English
Additional information: Reproduced with kind permission from eCM journal (www.ecmjournal.org)
Keywords: 3D collagen scaffolds, channelled architecture, physiological hypoxia, bone marrow stromal cells, hypoxia-inducible factor-I alpha, GROWTH-FACTOR, GLASS-FIBERS, GRADIENTS, HYPOXIA
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Ortho and MSK Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
URI: https://discovery.ucl.ac.uk/id/eprint/352089
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