Cheema, U; Alekseeva, T; Abou-Neel, EA; Brown, RA; (2010) SWITCHING OFF ANGIOGENIC SIGNALLING: CREATING CHANNELLED CONSTRUCTS FOR ADEQUATE OXYGEN DELIVERY IN TISSUE ENGINEERED CONSTRUCTS. EUR CELLS MATER , 20 274 - 281.

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Abstract

A major question in biomimetic tissue engineering is how much of the structure/function of native vasculature needs to be reproduced for effective tissue perfusion. O-2 supplied to cells in 3D scaffolds in vitro is initially dependent upon diffusion through the scaffold and cell consumption. Low O-2 (3%) enhances specific cell behaviours, but where O-2 is critically low (pathological hypoxia) cell survival becomes compromised. We measured real-time O-2 in 3D scaffolds and introduced micro-channelled architecture to controllably increase delivery of O-2 to cells and switch off the hypoxic response. Simple static micro-channelling gives adequate perfusion and can be used to control cell generated hypoxia-induced signalling.

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