Frost, JM;
Monk, D;
Stojilkovic-Mikic, T;
Woodfine, K;
Chitty, LS;
Murrell, A;
Stanier, P;
(2010)
Evaluation of allelic expression of imprinted genes in adult human blood.
PLoS One
, 5
(10)
, Article e13556. 10.1371/journal.pone.0013556.
![[thumbnail of 351631.pdf]](https://discovery.ucl.ac.uk/style/images/fileicons/application_pdf.png) Preview |
PDF
351631.pdf Download (2MB) |
Abstract
Imprinted genes are expressed from only one allele in a parent-of-origin dependent manner. Loss of imprinted (LOI) expression can result in a variety of human disorders and is frequently reported in cancer. Biallelic expression of imprinted genes in adult blood has been suggested as a useful biomarker and is currently being investigated in colorectal cancer. In general, the expression profiles of imprinted genes are well characterised during human and mouse fetal development, but not in human adults.
| Type: | Article |
|---|---|
| Title: | Evaluation of allelic expression of imprinted genes in adult human blood. |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0013556 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pone.0013556 |
| Language: | English |
| Additional information: | © 2010 Frost et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. This work was supported by grants from the Medical Research Council, the March of Dimes and Wellbeing of Women. AM and KW would like to acknowledge a Cancer Research UK Senior Cancer Research Fellowship and Association for International Cancer Research Project grant, as well as the support of The University of Cambridge, and Cancer Research UK. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
| Keywords: | Adult, Alleles, Female, Genomic Imprinting, Humans, Male, Middle Aged, Reverse Transcriptase Polymerase Chain Reaction |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Genetics and Genomic Medicine Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/351631 |
Archive Staff Only
 |
View Item |
