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Outcome of ATP-based tumor chemosensitivity assay directed chemotherapy in heavily pre-treated recurrent ovarian carcinoma

Sharma, S; Neale, MH; Di Nicolantonio, F; Knight, LA; Whitehouse, PA; Mercer, SJ; Higgins, BR; ... Cree, IA; + view all (2003) Outcome of ATP-based tumor chemosensitivity assay directed chemotherapy in heavily pre-treated recurrent ovarian carcinoma. BMC Cancer , 3 , Article 19. 10.1186/1471-2407-3-19. Green open access

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Abstract

BACKGROUND: We wished to evaluate the clinical response following ATP-Tumor Chemosensitivity Assay (ATP-TCA) directed salvage chemotherapy in a series of UK patients with advanced ovarian cancer. The results are compared with that of a similar assay used in a different country in terms of evaluability and clinical endpoints. METHODS: From November 1998 to November 2001, 46 patients with pre-treated, advanced ovarian cancer were given a total of 56 courses of chemotherapy based on in-vitro ATP-TCA responses obtained from fresh tumor samples or ascites. Forty-four patients were evaluable for results. Of these, 18 patients had clinically platinum resistant disease (relapse < 6 months after first course of chemotherapy). There was evidence of cisplatin resistance in 31 patients from their first ATP-TCA. Response to treatment was assessed by radiology, clinical assessment and tumor marker level (CA 125). RESULTS: The overall response rate was 59% (33/56) per course of chemotherapy, including 12 complete responses, 21 partial responses, 6 with stable disease, and 15 with progressive disease. Two patients were not evaluable for response having received just one cycle of chemotherapy: if these were excluded the response rate is 61%. Fifteen patients are still alive. Median progression free survival (PFS) was 6.6 months per course of chemotherapy; median overall survival (OAS) for each patient following the start of TCA-directed therapy was 10.4 months (95% confidence interval 7.9-12.8 months). CONCLUSION: The results show similar response rates to previous studies using ATP-TCA directed therapy in recurrent ovarian cancer. The assay shows high evaluability and this study adds weight to the reproducibility of results from different centres

Type: Article
Title: Outcome of ATP-based tumor chemosensitivity assay directed chemotherapy in heavily pre-treated recurrent ovarian carcinoma
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/1471-2407-3-19
Publisher version: http://dx.doi.org/10.1186/1471-2407-3-19
Language: English
Additional information: © 2003 Sharma et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
Keywords: Ascites, ASSAY, assessment, CA, cancer, Carcinoma, chemosensitivity, Chemotherapy, Cisplatin, clinical, Complete, confidence, cycle, disease, in vitro, In-vitro, INVITRO, LA, LEVEL, MARKER, Methods, November, outcome, ovarian, ovarian cancer, OVARIAN-CANCER, Partial, Patient, patients, PROGRESSION, Radiology, RATES, RECURRENT, RELAPSE, Reproducibility, Reproducibility of Results, Resistance, response, RESPONSES, Result, SAMPLE, SAMPLES, SERIES, SURVIVAL, TERM, therapy, treatment, Tumor, UK, WEIGHT
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/31201
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