Franzese, O.;
Kennedy, P.T.F.;
Gehring, A.J.;
Gotto, J.;
Williams, R.;
Maini, M.K.;
Bertoletti, A.;
(2005)
Modulation of the CD8+-T-cell response by CD4+ CD25+
regulatory T cells in patients with Hepatitis B
virus infection.
Journal of Virology
, 79
(6)
pp. 3322-3328.
10.1128/JVI.79.6.000�000.2005.
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Abstract
CD4+ CD25+ regulatory T cells have been shown to maintain peripheral tolerance against self and foreign antigens. In this study we analyzed the effect of circulating CD4+ CD25+ T cells on CD8+-T-cell responses of patients with chronic and resolved hepatitis B virus (HBV) infection. We demonstrated that circulating CD4+ CD25+ T cells modulate the function and expansion of HBV-specific CD8+ cells ex vivo in all patients, regardless of whether they have chronic or resolved HBV infection. The possible role of CD4+ CD25+ T cells in the pathogenesis of chronic HBV infection is not supported by these data. However, these results might have implications for optimizing future immunotherapeutic approaches to HBV treatment.
| Type: | Article |
|---|---|
| Title: | Modulation of the CD8+-T-cell response by CD4+ CD25+ regulatory T cells in patients with Hepatitis B virus infection |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1128/JVI.79.6.000�000.2005 |
| Publisher version: | http://intl-jvi.asm.org/cgi/content/abstract/79/6/... |
| Language: | English |
| Keywords: | immunological self-tolerance, lamivudine treatment, antigen, activation, disease, damage, vivo |
| UCL classification: | |
| URI: | https://discovery.ucl.ac.uk/id/eprint/309 |
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