UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Two Types of K⁺ Channel Subunit, Erg1 and KCNQ2/3, Contribute to the M-Like Current in a Mammalian Neuronal Cell

Selyanko, AA; Hadley, JK; Wood, IC; Abogadie, FC; Delmas, P; Buckley, NJ; London, B; (1999) Two Types of K⁺ Channel Subunit, Erg1 and KCNQ2/3, Contribute to the M-Like Current in a Mammalian Neuronal Cell. Journal of Neuroscience , 19 (18) 7742 - 7756. 10.1523/JNEUROSCI.19-18-07742.1999. Green open access

[img]
Preview
Text
Brown_Two Types of K⁺ Channel Subunit, Erg1 and KCNQ23, Contribute to the M-Like Current in a Mammalian Neuronal Cell_VoR.pdf - Published version

Download (422kB) | Preview

Abstract

The potassium M current was originally identified in sympathetic ganglion cells, and analogous currents have been reported in some central neurons and also in some neural cell lines. It has recently been suggested that the M channel in sympathetic neurons comprises a heteromultimer of KCNQ2 and KCNQ3 (Wang et al., 1998) but it is unclear whether all other M-like currents are generated by these channels. Here we report that the M-like current previously described in NG108–15 mouse neuroblastoma x rat glioma cells has two components, “fast” and “slow”, that may be differentiated kinetically and pharmacologically. We provide evidence from PCR analysis and expression studies to indicate that these two components are mediated by two distinct molecular species of K+ channel: the fast component resembles that in sympathetic ganglia and is probably carried byKCNQ2/3 channels, whereas the slow component appears to be carried by merg1a channels. Thus, the channels generating M-like currents in different cells may be heterogeneous in molecular composition.

Type: Article
Title: Two Types of K⁺ Channel Subunit, Erg1 and KCNQ2/3, Contribute to the M-Like Current in a Mammalian Neuronal Cell
Open access status: An open access version is available from UCL Discovery
DOI: 10.1523/JNEUROSCI.19-18-07742.1999
Publisher version: https://doi.org/10.1523/JNEUROSCI.19-18-07742.1999
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: potassium channels, neuroblastoma x glioma hybrid, cells, M current, sympathetic, neuron, Erg1, KCNQ
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: https://discovery.ucl.ac.uk/id/eprint/22399
Downloads since deposit
70Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item