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Contextual novelty changes reward representations in the striatum

Guitart-Masip, M.; Bunzeck, N.; Stephan, K. E.; Dolan, R. J.; Düzel, E.; (2010) Contextual novelty changes reward representations in the striatum. Journal of Neuroscience , 30 (5) pp. 1721-1726. 10.1523/JNEUROSCI.5331-09.2010. Green open access

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Abstract

Reward representation in ventral striatum is boosted by perceptual novelty, although the mechanism of this effect remains elusive. Animal studies indicate a functional loop (Lisman and Grace, 2005) that includes hippocampus, ventral striatum, and midbrain as being important in regulating salience attribution within the context of novel stimuli. According to this model, reward responses in ventral striatum or midbrain should be enhanced in the context of novelty even if reward and novelty constitute unrelated, independent events. Using fMRI, we show that trials with reward-predictive cues and subsequent outcomes elicit higher responses in the striatum if preceded by an unrelated novel picture, indicating that reward representation is enhanced in the context of novelty. Notably, this effect was observed solely when reward occurrence, and hence reward-related salience, was low. These findings support a view that contextual novelty enhances neural responses underlying reward representation in the striatum and concur with the effects of novelty processing as predicted by the model of Lisman and Grace (2005).

Type: Article
Title: Contextual novelty changes reward representations in the striatum
Identifier: PMID:20130181
Open access status: An open access version is available from UCL Discovery
DOI: 10.1523/JNEUROSCI.5331-09.2010
Publisher version: http://dx.doi.org/10.1523/JNEUROSCI.5331-09.2010
Language: English
Additional information: Published by the Society of Neuroscience 2010. Article reproduced here for non-commercial purposes under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license. For further information see: http://creativecommons.org/licenses/by-nc-sa/3.0/ Update: 20.5.13 This work is licensed under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. The license allows you to copy, distribute, and transmit the work, as well as adapting it. However, you must attribute the work to the author (but not in any way that suggests that they endorse you or your use of the work), and cannot use the work for commercial purposes without prior permission of the author. If you alter or build upon this work, you can distribute the resulting work only under the same or similar license to this one. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ or send a letter to Creative Commons, 444 Castro Street, Suite 900, Mountain View, California, 94041, USA.
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Institute of Cognitive Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/19607
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