Monot, M;
Honore, N;
Garnier, T;
Zidane, N;
Sherafi, D;
Paniz-Mondolfi, A;
Matsuoka, M;
... Cole, ST; + view all
(2009)
Comparative genomic and phylogeographic analysis of Mycobacterium leprae.
NAT GENET
, 41
(12)
1282 - U39.
10.1038/ng.477.
![[thumbnail of 18862.pdf]](https://discovery.ucl.ac.uk/style/images/fileicons/application_pdf.png) Preview |
PDF
18862.pdf Download (135kB) |
Preview |
PDF (Figure1)
18862_Figure1.pdf Download (5MB) |
Preview |
PDF (Figure2)
18862_Figure2.pdf Download (1MB) |
Preview |
PDF (Figure3)
18862_Figure3.pdf Download (3MB) |
Preview |
PDF (Figure4)
18862_Figure4.pdf Download (2MB) |
Preview |
PDF (Figure5)
18862_Figure5.pdf Download (5MB) |
Abstract
Reductive evolution and massive pseudogene formation have shaped the 3.31-Mb genome of Mycobacterium leprae, an unculturable obligate pathogen that causes leprosy in humans. The complete genome sequence of M. leprae strain Br4923 from Brazil was obtained by conventional methods (6 x coverage), and Illumina resequencing technology was used to obtain the sequences of strains Thai53 (38 x coverage) and NHDP63 (46 x coverage) from Thailand and the United States, respectively. Whole-genome comparisons with the previously sequenced TN strain from India revealed that the four strains share 99.995% sequence identity and differ only in 215 polymorphic sites, mainly SNPs, and by 5 pseudogenes. Sixteen interrelated SNP subtypes were defined by genotyping both extant and extinct strains of M. leprae from around the world. The 16 SNP subtypes showed a strong geographical association that reflects the migration patterns of early humans and trade routes, with the Silk Road linking Europe to China having contributed to the spread of leprosy.
| Type: | Article |
|---|---|
| Title: | Comparative genomic and phylogeographic analysis of Mycobacterium leprae |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/ng.477 |
| Keywords: | NUMBER TANDEM REPEATS, HELICOBACTER-PYLORI, LEPROSY PATIENTS, YERSINIA-PESTIS, CAUSATIVE AGENT, BURULI ULCER, TUBERCULOSIS, SEQUENCE, EVOLUTION, POPULATIONS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/18862 |
Archive Staff Only
 |
View Item |
