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Theoretical investigation of measuring cerebral blood flow in the adult human head using bolus Indocyanine Green injection and near-infrared spectroscopy

Leung, TS; Tachtsidis, I; Tisdall, M; Smith, M; Delpy, DT; Elwell, CE; (2007) Theoretical investigation of measuring cerebral blood flow in the adult human head using bolus Indocyanine Green injection and near-infrared spectroscopy. APPLIED OPTICS , 46 (10) 1604 - 1614. 10.1364/AO.46.001604. Green open access

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Abstract

To investigate the accuracy of measuring cerebral blood flow (CBF) using a bolus injection of Indocyanine Green (ICG) detected by near-infrared spectroscopy in adult human heads, simulations were performed using a two-layered model representing the extracerebral and intracerebral layers. Modeled optical data were converted into tissue ICG concentration using either the one-detector modified Beer-Lambert law (MBLL) method, or the two-detector partial path-length (PPL) method. The CBFs were estimated using deconvolution and blood flow index techniques. Using the MBLL method, the CBFs were significantly underestimated but the PPL method improved their accuracy and robustness, especially when used as relative measures. The dispersion of the arterial input function also affected the CBF estimates. (c) 2007 Optical Society of America.

Type: Article
Title: Theoretical investigation of measuring cerebral blood flow in the adult human head using bolus Indocyanine Green injection and near-infrared spectroscopy
Location: Ft Lauderdale, FL
Open access status: An open access version is available from UCL Discovery
DOI: 10.1364/AO.46.001604
Publisher version: http://dx.doi.org/10.1364/AO.46.001604
Additional information: © 2007 Optical Society of America
Keywords: NONINVASIVE MEASUREMENT, OPTICAL-PROPERTIES, DIFFUSE-REFLECTANCE, MAGNETIC-RESONANCE, NEWBORN PIGLETS, DYE DILUTION, TISSUE, BRAIN, HEMODYNAMICS, QUANTIFICATION
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/187598
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