Breathnach, AS;
McHugh, TD;
Butcher, PD;
(2010)
Prevalence and clinical correlations of genetic subtypes of Giardia lamblia in an urban setting.
EPIDEMIOL INFECT
, 138
(10)
1459 - 1467.
10.1017/S0950268810000208.
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Abstract
The clinical significance of different genetic subtypes or assemblages of Giardia lamblia is uncertain. Cases of giardiasis in south-west London between 1999 and 2005 were studied, comparing molecular-typing results with clinical and epidemiological findings from routine surveillance. We identified 819 cases, of whom 389 returned surveillance questionnaires. A subset of 267 faecal samples was submitted for typing by sequencing of the triose phosphate isomerase (tpi) and ribosomal RNA genes, and/or a separate duplex PCR of the tpi gene. Typing was successful in 199 (75%) samples by at least one of the molecular methods. Assemblage A accounted for 48 (24%) samples and Assemblage B for 145 (73%); six (3%) were mixed. Both assemblages had similar seasonality, age distribution and association with travel. Clinical features were available for 59 successfully typed cases: both assemblages caused similar illness, but Assemblage A was significantly more frequently associated with fever than Assemblage B.
Type: | Article |
---|---|
Title: | Prevalence and clinical correlations of genetic subtypes of Giardia lamblia in an urban setting |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1017/S0950268810000208 |
Publisher version: | http://dx.doi.org/10.1017/S0950268810000208 |
Language: | English |
Additional information: | © 2010 Cambridge University Press |
Keywords: | Gastrointestinal infections, genetics, Giardia lamblia, molecular epidemiology, typing, FRAGMENT-LENGTH-POLYMORPHISM, HUMAN FECES, DUODENALIS, INTESTINALIS, GENOTYPE, DIARRHEA, CHILDREN, ANIMALS, HUMANS, LOCUS |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
URI: | https://discovery.ucl.ac.uk/id/eprint/172143 |
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