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Prevalence and clinical correlations of genetic subtypes of Giardia lamblia in an urban setting

Breathnach, AS; McHugh, TD; Butcher, PD; (2010) Prevalence and clinical correlations of genetic subtypes of Giardia lamblia in an urban setting. EPIDEMIOL INFECT , 138 (10) 1459 - 1467. 10.1017/S0950268810000208. Green open access

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Abstract

The clinical significance of different genetic subtypes or assemblages of Giardia lamblia is uncertain. Cases of giardiasis in south-west London between 1999 and 2005 were studied, comparing molecular-typing results with clinical and epidemiological findings from routine surveillance. We identified 819 cases, of whom 389 returned surveillance questionnaires. A subset of 267 faecal samples was submitted for typing by sequencing of the triose phosphate isomerase (tpi) and ribosomal RNA genes, and/or a separate duplex PCR of the tpi gene. Typing was successful in 199 (75%) samples by at least one of the molecular methods. Assemblage A accounted for 48 (24%) samples and Assemblage B for 145 (73%); six (3%) were mixed. Both assemblages had similar seasonality, age distribution and association with travel. Clinical features were available for 59 successfully typed cases: both assemblages caused similar illness, but Assemblage A was significantly more frequently associated with fever than Assemblage B.

Type: Article
Title: Prevalence and clinical correlations of genetic subtypes of Giardia lamblia in an urban setting
Open access status: An open access version is available from UCL Discovery
DOI: 10.1017/S0950268810000208
Publisher version: http://dx.doi.org/10.1017/S0950268810000208
Language: English
Additional information: © 2010 Cambridge University Press
Keywords: Gastrointestinal infections, genetics, Giardia lamblia, molecular epidemiology, typing, FRAGMENT-LENGTH-POLYMORPHISM, HUMAN FECES, DUODENALIS, INTESTINALIS, GENOTYPE, DIARRHEA, CHILDREN, ANIMALS, HUMANS, LOCUS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
URI: https://discovery.ucl.ac.uk/id/eprint/172143
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