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The relationship between beta-2-microglobulin, CD4 lymphocyte count, AIDS and death in HIV-positive individuals

Mocroft, A; Johnson, MA; Sabin, CA; Bofill, M; Janossy, G; Phillips, AN; (1997) The relationship between beta-2-microglobulin, CD4 lymphocyte count, AIDS and death in HIV-positive individuals. EPIDEMIOL INFECT , 118 (3) 259 - 266. Green open access

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Abstract

The relationship, in 539 individuals infected with the human immunodeficiency virus (HIV), between two prognostic markers, the CD4 count and beta-2-microglobulin (B2M), and the development of the acquired immunodeficiency syndrome (AIDS) and death was investigated. Cox proportional hazards models were used to determine the risk of AIDS or death. In a multivariate model which adjusted for demographic factors and treatment, the most recent measurements of B2M (relative hazard (RH) 1.37 per g/l higher) and CD4 count (RH 2.17 per log-unit lower) were both significantly associated with the development of AIDS. Similarly, in a multivariate model which additionally adjusted for the development of AIDS as a time dependant covariate, there was a strong relationship with risk of death for the most recent measurements of B2M (RH 1.34 per g/l higher), and CD4 lymphocyte count (RH 1.91 per log-unit lower). A difference in the level of B2M could be used among patients with similar CD4 counts as an indicator of increased risk of progression to AIDS or death. Using the most recent values of these markers provides a better estimate of the risk of AIDS or death, compared to the more common method of analysis, where baseline values of the markers are used.

Type: Article
Title: The relationship between beta-2-microglobulin, CD4 lymphocyte count, AIDS and death in HIV-positive individuals
Open access status: An open access version is available from UCL Discovery
Publisher version: http://journals.cambridge.org/action/displayAbstra...
Language: English
Additional information: © 1997 Cambridge University Press
Keywords: ACQUIRED-IMMUNODEFICIENCY-SYNDROME, IMMUNOLOGICAL MARKERS, INFECTED PATIENTS, PROGRESSION, SURVIVAL, PREDICTORS, DISEASE, COHORT, LEVEL, TIME
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health > Infection and Population Health
URI: https://discovery.ucl.ac.uk/id/eprint/158570
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