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Thalamic input to auditory cortex is locally heterogeneous but globally tonotopic

Vasquez-Lopez, SA; Weissenberger, Y; Lohse, M; Keating, P; King, AJ; Dahmen, JC; (2017) Thalamic input to auditory cortex is locally heterogeneous but globally tonotopic. eLife , 2017 (6) , Article e25141. 10.7554/eLife.25141. Green open access

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Abstract

Topographic representation of the receptor surface is a fundamental feature of sensory cortical organization. This is imparted by the thalamus, which relays information from the periphery to the cortex. To better understand the rules governing thalamocortical connectivity and the origin of cortical maps, we used in vivo two-photon calcium imaging to characterize the properties of thalamic axons innervating different layers of mouse auditory cortex. Although tonotopically organized at a global level, we found that the frequency selectivity of individual thalamocortical axons is surprisingly heterogeneous, even in layers 3b/4 of the primary cortical areas, where the thalamic input is dominated by the lemniscal projection. We also show that thalamocortical input to layer 1 includes collaterals from axons innervating layers 3b/4 and is largely in register with the main input targeting those layers. Such locally varied thalamocortical projections may be useful in enabling rapid contextual modulation of cortical frequency representations.

Type: Article
Title: Thalamic input to auditory cortex is locally heterogeneous but globally tonotopic
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.7554/eLife.25141
Publisher version: https://doi.org/10.7554/eLife.25141
Language: English
Additional information: Copyright © 2017 Vasquez-Lopez et al. This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) permitting unrestricted use and redistribution provided that the original author and source are credited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > The Ear Institute
URI: https://discovery.ucl.ac.uk/id/eprint/1574709
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