Maloca, PM;
Tufail, A;
Egan, C;
Zweifel, S;
Hasler, PW;
Petzold, A;
Ramos de Carvalho, JE;
(2017)
Volume rendering of superficial optic disc drusen: A possible new imaging technique using optical coherence tomography angiography.
Spektrum der Augenheilkunde
, 31
(6)
pp. 288-293.
10.1007/s00717-017-0359-4.
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Abstract
BACKGROUND: Optic disc drusen (ODD) are calcified deposits potentially caused by disturbances in axonal metabolism. The clinical course and visual impairment of ODD is usually mild; however, significant ocular morbidity may occur, such as visual field defects and retinal haemorrhages. Optic disc drusen may pose a diagnostic dilemma and differentiating these from other entities that can lead to similar compressive axonal distress is imperative. We present a novel technique for three-dimensional (3D) characterisation of superficial ODD based on 3D volume rendering of optical coherence tomography angiography (3DOCTA) scans. MATERIAL AND METHODS: Optical coherence tomography (Cirrus™ HD-OCT Model 5000 with AngioPlex, Carl Zeiss Meditec, Inc., Dublin, USA) scans were obtained from the optic nerve head of a healthy 22-year-old female. Consequently, 3D structural OCT data and OCTA were analysed, enabling ODD segmentation and spatial characterization. RESULTS: Volumetric analysis of superficial ODD showed a maximal drusen horizontal diameter of 223 μm, maximal vertical diameter of 268 μm, surface area of 6617 μm 2 and volume measurement of 12,875 μm 3. The drusen were characterised by a connected network of multiple drusen islands instead of forming a dense mass. Multiple vascular channels with perforating vessels were found across the drusen. CONCLUSION: Three-dimensional volume rendering of OCTA scans provided new insight on the spatio-anatomical features of superficial ODD. The new features herein described, namely multilobulated drusen islands and intradrusen channels, may directly contribute to the pathogenic events leading to transient non-embolic visual loss and small vessel occlusion secondary to ODD.
| Type: | Article |
|---|---|
| Title: | Volume rendering of superficial optic disc drusen: A possible new imaging technique using optical coherence tomography angiography |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s00717-017-0359-4 |
| Publisher version: | http://dx.doi.org/10.1007/s00717-017-0359-4 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Three-dimensional volume rendering, Optical coherence tomography angiography, Optic disc drusen, Retinal vessels, Perfusion |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1572077 |
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