Kroesen, VM;
Groschel, MI;
Martinson, N;
Zumla, A;
Maeurer, M;
van der Werf, TS;
Vilaplana, C;
(2017)
Non-Steroidal Anti-inflammatory Drugs As Host-Directed Therapy for Tuberculosis: A Systematic Review.
Frontiers in Immunology
, 8
, Article 772. 10.3389/fimmu.2017.00772.
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Abstract
Lengthy, antimicrobial therapy targeting the pathogen is the mainstay of conventional tuberculosis treatment, complicated by emerging drug resistances. Host-directed therapies, including non-steroidal anti-inflammatory drugs (NSAIDs), in contrast, target host factors to mitigate disease severity. In the present Systematic Review, we investigate whether NSAIDs display any effects as therapy of TB and discuss possible mechanisms of action of NSAIDs as adjunctive therapy of TB. Ten studies, seven preclinical studies in mice and three clinical trials, were included and systematically reviewed. Our results point toward a beneficial effect of NSAIDs as adjunct to current TB therapy regimens, mediated by decreased lung pathology balancing host-immune reaction. The determination of the best timing for their administration in order to obtain the potential beneficial effects needs further investigation. Even if the preclinical evidence requires clinical evaluation, NSAIDs might represent a potential safe, simple, and cheap improvement in therapy of TB.
| Type: | Article |
|---|---|
| Title: | Non-Steroidal Anti-inflammatory Drugs As Host-Directed Therapy for Tuberculosis: A Systematic Review |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fimmu.2017.00772 |
| Publisher version: | http://dx.doi.org/10.3389/fimmu.2017.00772 |
| Language: | English |
| Additional information: | © 2017 Kroesen, Gröschel, Martinson, Zumla, Maeurer, van der Werf and Vilaplana. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Immunology, non-steroidal anti-inflammatory drugs, host-directed therapies, tuberculosis, systematic review, infectious diseases, MYCOBACTERIUM-TUBERCULOSIS, ANTITUBERCULOSIS AGENTS, ASPIRIN, DICLOFENAC, MENINGITIS, INHIBITION, IBUPROFEN, ACID, CYCLOOXYGENASE-2, MACROPHAGE |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1570249 |
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