Bologna, M; Paparella, G; Fabbrini, A; Leodori, G; Rocchi, L; Hallett, M; Berardelli, A; (2016) Effects of cerebellar theta-burst stimulation on arm and neck movement kinematics in patients with focal dystonia. Clinical Neurophysiology , 127 (11) pp. 3472-3479. 10.1016/j.clinph.2016.09.008.

Preview	Text Rocchi_2_Bologna et al., 2016 Cerebellar cTBS dystonia_Abstract_CLINPH R1.pdf - Accepted Version Download (85kB) | Preview
Preview	Text Rocchi_2_Bologna et al., 2016 Cerebellar cTBS dystonia_Manuscript_CLINPH_R1_R1.pdf - Accepted Version Download (263kB) | Preview
Preview	Text Rocchi_3_Bologna et a., 2016_Cerebellar cTBS dystonia_CLINPH_Table 1 R1.pdf - Accepted Version Download (9kB) | Preview
Preview	Text Rocchi_4_Bologna et al, 2016_Cerebellar cTBS dystonia_CLINPH_Table 2 R1.pdf - Accepted Version Download (29kB) | Preview
Preview	Text Rocchi_5_Bologna et al, 2016_Cerebellar cTBS dystonia_CLINPH_Table 3 R1.pdf - Accepted Version Download (17kB) | Preview
Preview	Image Rocchi_6_Bologna et al., 2016_Cerebellar cTBS dystonia_CLINPH_Figure 1_MEP 300 dpi_R1.jpg - Accepted Version Download (570kB) | Preview
Preview	Image Rocchi_7_Bologna et al., 2016_Cerebellar cTBS dystonia_CLINPH_Figure 2_CS 300 dpi R1.jpg - Accepted Version Download (189kB) | Preview
Preview	Text Rocchi_8_Bologna et al., 2016_Cerebellar cTBS dystonia_CLINPH_Suppl.Table1 R1.pdf - Accepted Version Download (12kB) | Preview
Preview	Text Rocchi_9_Bologna et al., 2016_Cerebellar cTBS dystonia_CLINPH_Supp.Table2 R1.pdf - Accepted Version Download (106kB) | Preview
Preview	Text Rocchi_10_Bologna et al., 2016_Cerebellar cTBS dystonia_CLINPH_Supp.Table3 R1.pdf - Accepted Version Download (92kB) | Preview
Preview	Text Rocchi_11_Bologna et al., 2016_Cerebellar cTBS dystonia_CLINPH_Suppl. Results R1.pdf - Accepted Version Download (165kB) | Preview

Abstract

OBJECTIVE: To investigate the cerebellar inhibitory influence on the primary motor cortex in patients with focal dystonia using a cerebellar continuous theta-burst stimulation protocol (cTBS) and to evaluate any relationship with movement abnormalities. METHODS: Thirteen patients with focal hand dystonia, 13 patients with cervical dystonia and 13 healthy subjects underwent two sessions: (i) cTBS over the cerebellar hemisphere (real cTBS) and (ii) cTBS over the neck muscles (sham cTBS). The effects of cerebellar cTBS were quantified as excitability changes in the contralateral primary motor cortex, as well as possible changes in arm and neck movements in patients. RESULTS: Real cerebellar cTBS reduced the excitability in the contralateral primary motor cortex in healthy subjects and in patients with cervical dystonia, though not in patients with focal hand dystonia. There was no correlation between changes in primary motor cortex excitability and arm and neck movement kinematics in patients. There were no changes in clinical scores or in kinematic measures, after either real or sham cerebellar cTBS in patients. CONCLUSIONS: The reduced cerebellar inhibitory modulation of primary motor cortex excitability in focal dystonia may be related to the body areas affected by dystonia as opposed to being a widespread pathophysiological abnormality. SIGNIFICANCE: The present study yields information on the differential role played by the cerebellum in the pathophysiology of different focal dystonias.

Download activity - last month

Export as CSVXMLJSON

Download activity - last 12 months

Export as XMLCSVJSON

Downloads by country - last 12 months

Export as CSVXMLJSON

Archive Staff Only

View Item