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Mortality gap for people with bipolar disorder and schizophrenia: UK-based cohort study 2000-2014

Hayes, JF; Marston, L; Walters, K; King, MB; Osborn, DPJ; (2017) Mortality gap for people with bipolar disorder and schizophrenia: UK-based cohort study 2000-2014. The British Journal of Psychiatry 10.1192/bjp.bp.117.202606. Green open access

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Abstract

BACKGROUND: Bipolar disorder and schizophrenia are associated with increased mortality relative to the general population. There is an international emphasis on decreasing this excess mortality. AIMS: To determine whether the mortality gap between individuals with bipolar disorder and schizophrenia and the general population has decreased. METHOD: A nationally representative cohort study using primary care electronic health records from 2000 to 2014, comparing all patients diagnosed with bipolar disorder or schizophrenia and the general population. The primary outcome was all-cause mortality. RESULTS: Individuals with bipolar disorder and schizophrenia had elevated mortality (adjusted hazard ratio (HR) = 1.79, 95% CI 1.67-1.88 and 2.08, 95% CI 1.98-2.19 respectively). Adjusted HRs for bipolar disorder increased by 0.14/year (95% CI 0.10-0.19) from 2006 to 2014. The adjusted HRs for schizophrenia increased gradually from 2004 to 2010 (0.11/year, 95% CI 0.04-0.17) and rapidly after 2010 (0.34/year, 95% CI 0.18-0.49). CONCLUSIONS: The mortality gap between individuals with bipolar disorder and schizophrenia, and the general population is widening.

Type: Article
Title: Mortality gap for people with bipolar disorder and schizophrenia: UK-based cohort study 2000-2014
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1192/bjp.bp.117.202606
Publisher version: http://dx.doi.org/10.1192/bjp.bp.117.202606
Language: English
Additional information: © The Royal College of Psychiatrists 2017. This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY) licence.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Primary Care and Population Health
URI: https://discovery.ucl.ac.uk/id/eprint/1564951
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