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Sensitivity of OGSE activeax to microstructural dimensions on a clinical scanner

Kakkar, LS; Atkinson, D; Chan, RW; Siow, B; Ianus, A; Drobnjak, I; (2017) Sensitivity of OGSE activeax to microstructural dimensions on a clinical scanner. In: Hege, H-C and Hoffman, D and Johnson, CR and Polthier, K and Rumpf, M, (eds.) Computational Diffusion MRI MICCAI 2016. Mathematics and Visualization. (pp. pp. 85-97). Springer: Cham, Switzerland.

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Abstract

Axon diameter can play a key role in the function and performance of nerve pathways of the central and peripheral nervous system. Previously, a number of techniques to measure axon diameter using diffusion MR I have been proposed, majority of which uses single diffusion encoding (SDE) spin-echo sequence. However, recent theoretical research suggests that low-frequency oscillating gradient spin echo (OGSE) offers benefits over SDE for imaging diameters when fibres are of unknown orientation. Furthermore, it suggests that resolution limit for clinical scanners (gradient strength of 60–80 mT/m) is ~ 6 µm. Here we investigate the sensitivity of OGSE to fibre diameters experimentally on a clinical scanner, using microcapillaries of unknown orientation. We use the orientationally invariant OGSE ActiveAx method to image microcapillaries with diameters of 5, 10 or 20 µm. As predicted by theory, we find that 5 µm diameters are undistinguishable from zero. Furthermore, we find accurate and precise estimates for 10 and 20 µm. Finally, we find that low frequency oscillating gradient waveforms are optimal for accurate diameter estimation.

Type: Proceedings paper
Title: Sensitivity of OGSE activeax to microstructural dimensions on a clinical scanner
Event: Computational Diffusion MRI MICCAI 2016. Mathematics and Visualization.
ISBN-13: 9783319541297
DOI: 10.1007/978-3-319-54130-3_7
Publisher version: http://doi.org/10.1007/978-3-319-54130-3_7
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Axon diameter, Diffusion MR, Microcapillary diameter , Microstructure imaging, OGSE, Oscillating gradient spin echo, Pore diameter, Pore size
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Metabolism and Experi Therapeutics
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
URI: https://discovery.ucl.ac.uk/id/eprint/1561987
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