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The effectiveness of demineralized cortical bone matrix in a chronic rotator cuff tear model.

Thangarajah, T; Henshaw, F; Sanghani-Kerai, A; Lambert, SM; Blunn, GW; Pendegrass, CJ; (2017) The effectiveness of demineralized cortical bone matrix in a chronic rotator cuff tear model. Journal of Shoulder and Elbow Surgery , 26 (4) pp. 619-626. 10.1016/j.jse.2017.01.003. Green open access

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Abstract

BACKGROUND: The purpose of this study was to assess the effect of demineralized bone matrix (DBM) on rotator cuff tendon-bone healing. The hypothesis was that compared with a commercially available dermal matrix scaffold, DBM would result in a higher bone mineral density and regenerate a morphologically superior enthesis in a rat model of chronic rotator cuff degeneration. METHODS: Eighteen female Wistar rats underwent unilateral detachment of the supraspinatus tendon. Three weeks later, tendon repair was carried out in animals randomized into 3 groups: group 1 animals were repaired with DBM (n = 6); group 2 received augmentation with the dermal scaffold (n = 6); and group 3 (controls) underwent nonaugmented tendon-bone repair (n = 6). Specimens were retrieved at 6 weeks postoperatively for histologic analysis and evaluation of bone mineral density. RESULTS: No failures of tendon-bone healing were noted throughout the study. All groups demonstrated closure of the tendon-bone gap with a fibrocartilaginous interface. Dermal collagen specimens exhibited a disorganized structure with significantly more abnormal collagen fiber arrangement and cellularity than in the DBM-based repairs. Nonaugmented repairs exhibited a significantly higher bone mineral density than in DBM and the dermal collagen specimens and were not significantly different from control limbs that were not operated on. CONCLUSION: The application of DBM to a rat model of chronic rotator cuff degeneration did not improve the composition of the healing enthesis compared with nonaugmented controls and a commercially available scaffold. However, perhaps the most important finding of this study was that the control group demonstrated a similar outcome to augmented repairs.

Type: Article
Title: The effectiveness of demineralized cortical bone matrix in a chronic rotator cuff tear model.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jse.2017.01.003
Publisher version: http://doi.org/10.1016/j.jse.2017.01.003
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Animal model, enthesis healing, rotator cuff, scaffold, shoulder, tendon-bone, tissue engineering, Acellular Dermis, Animals, Biocompatible Materials, Bone Density, Bone Matrix, Chronic Disease, Cortical Bone, Female, Rats, Rats, Wistar, Rotator Cuff Injuries, Tissue Scaffolds, Wound Healing
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Ortho and MSK Science
URI: https://discovery.ucl.ac.uk/id/eprint/1561744
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