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Biocompatible pH-responsive nanoparticles with a core-anchored multilayer shell of triblock copolymers for enhanced cancer therapy

Ellis, E; Zhang, K; Lin, Q; Ye, E; Poma, A; Battaglia, G; Loh, XJ; (2017) Biocompatible pH-responsive nanoparticles with a core-anchored multilayer shell of triblock copolymers for enhanced cancer therapy. Journal of Materials Chemistry B , 5 (23) pp. 4421-4425. 10.1039/c7tb00654c. Green open access

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Abstract

Drug nanocarriers are synthesised via a facile self-assembly approach using gold nanoparticles (Au NPs) as a structural core. The nanocarriers feature a multilayer shell of POEGMA–PDPA–PMPC triblock copolymers with a chain-end thiol functional group for anchoring to the Au NP surface. This water-soluble triblock copolymer was synthesised via atom transfer radical polymerisation (ATRP) from a bi-functional initiator containing a disulphide bridge. The resultant nanocarriers exhibit high biocompatibility plus excellent colloidal stability and antifouling capability in bio-media (50% PBS/FBS). Encapsulation and release of a hydrophobic drug can be effectively triggered by a pH-stimulus. Meanwhile drug-loaded nanocarriers show enhanced efficacy towards cancer cells compared to plain drug.

Type: Article
Title: Biocompatible pH-responsive nanoparticles with a core-anchored multilayer shell of triblock copolymers for enhanced cancer therapy
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/c7tb00654c
Publisher version: http://doi.org/10.1039/c7tb00654c
Language: English
Additional information: This journal is © The Royal Society of Chemistry 2017. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Keywords: Science & Technology, Technology, Materials Science, Biomaterials, Materials Science, PEPTIDE AMPHIPHILE VESICLES, DRUG-DELIVERY, GOLD NANOPARTICLES, POLYMERSOMES, SYSTEMS, CELLS, ENCAPSULATION, DOXORUBICIN, TOXICITY, RELEASE
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > MAPS Faculty Office
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > MAPS Faculty Office > Institute for Materials Discovery
URI: https://discovery.ucl.ac.uk/id/eprint/1558748
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