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Performance of novel high throughput multi electrospray systems for forming of polymeric micro/nanoparticles

Parhizkar, M; Reardon, PJT; Knowles, JC; Browning, RJ; Stride, E; Pedley, RB; Grego, T; (2017) Performance of novel high throughput multi electrospray systems for forming of polymeric micro/nanoparticles. Materials and Design , 126 pp. 73-84. 10.1016/j.matdes.2017.04.029. Green open access

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Abstract

In order to maintain a stable cone-jet mode in electrospray low flow rates are used while most applications require a high throughput. We compare two different designs of the multiple electrospray system in order to increase the output for large scale production applications. In this study, the solution was fed through four separate needles that were attached to either a circular or a rectangular metallic plate that were connected to a high voltage DC power supply. The behaviour of the electrospray jets as well as the deposition of particles were investigated. It was shown that the throughput of particles was increased while particles with narrow size distribution were produced from all four uniform electrospray jets.

Type: Article
Title: Performance of novel high throughput multi electrospray systems for forming of polymeric micro/nanoparticles
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.matdes.2017.04.029
Publisher version: http://doi.org/10.1016/j.matdes.2017.04.029
Language: English
Additional information: © 2017 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/).
Keywords: Electrohydrodynamic; Electrospray; Multiplexing electrospray; Particles; Polymer; Carriers; Drug delivery
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Biomaterials and Tissue Eng
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/1555692
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