Dixon, SC;
Nagle, CM;
Wentzensen, N;
Trabert, B;
Beeghly-Fadiel, A;
Schildkraut, JM;
Moysich, KB;
... Webb, PM; + view all
(2017)
Use of common analgesic medications and ovarian cancer survival: results from a pooled analysis in the Ovarian Cancer Association Consortium.
British Journal of Cancer
, 116
(9)
pp. 1223-1228.
10.1038/bjc.2017.68.
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Abstract
BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) have been associated with improved survival in some cancers, but evidence for ovarian cancer is limited. Methods: Pooling individual-level data from 12 Ovarian Cancer Association Consortium studies, we evaluated the association between self-reported, pre-diagnosis use of common analgesics and overall/progression-free/disease-specific survival among 7694 women with invasive epithelial ovarian cancer (4273 deaths). RESULTS: Regular analgesic use (at least once per week) was not associated with overall survival (pooled hazard ratios, pHRs (95% confidence intervals): aspirin 0.96 (0.88–1.04); non-aspirin NSAIDs 0.97 (0.89–1.05); acetaminophen 1.01 (0.93–1.10)), nor with progression-free/disease-specific survival. There was however a survival advantage for users of any NSAIDs in studies clearly defining non-use as less than once per week (pHR ¼ 0.89 (0.82–0.98)). CONCLUSIONS: Although this study did not show a clear association between analgesic use and ovarian cancer survival, further investigation with clearer definitions of use and information about post-diagnosis use is warranted.
| Type: | Article |
|---|---|
| Title: | Use of common analgesic medications and ovarian cancer survival: results from a pooled analysis in the Ovarian Cancer Association Consortium |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/bjc.2017.68 |
| Publisher version: | http://dx.doi.org/10.1038/bjc.2017.68 |
| Language: | English |
| Additional information: | © 2017 Cancer Research UK. All rights reserved |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Oncology, Ovarian Cancer, Aspirin, Nonsteroidal Anti-Inflammatory Drugs, NSAID, Paracetamol, Acetaminophen, Pooled Analysis, Survival, Nonsteroidal Antiinflammatory Drugs, Aspirin, Metaanalysis, Diagnosis |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1552440 |
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