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Use of common analgesic medications and ovarian cancer survival: results from a pooled analysis in the Ovarian Cancer Association Consortium

Dixon, SC; Nagle, CM; Wentzensen, N; Trabert, B; Beeghly-Fadiel, A; Schildkraut, JM; Moysich, KB; ... Webb, PM; + view all (2017) Use of common analgesic medications and ovarian cancer survival: results from a pooled analysis in the Ovarian Cancer Association Consortium. British Journal of Cancer , 116 (9) pp. 1223-1228. 10.1038/bjc.2017.68. Green open access

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Abstract

BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) have been associated with improved survival in some cancers, but evidence for ovarian cancer is limited. Methods: Pooling individual-level data from 12 Ovarian Cancer Association Consortium studies, we evaluated the association between self-reported, pre-diagnosis use of common analgesics and overall/progression-free/disease-specific survival among 7694 women with invasive epithelial ovarian cancer (4273 deaths). RESULTS: Regular analgesic use (at least once per week) was not associated with overall survival (pooled hazard ratios, pHRs (95% confidence intervals): aspirin 0.96 (0.88–1.04); non-aspirin NSAIDs 0.97 (0.89–1.05); acetaminophen 1.01 (0.93–1.10)), nor with progression-free/disease-specific survival. There was however a survival advantage for users of any NSAIDs in studies clearly defining non-use as less than once per week (pHR ¼ 0.89 (0.82–0.98)). CONCLUSIONS: Although this study did not show a clear association between analgesic use and ovarian cancer survival, further investigation with clearer definitions of use and information about post-diagnosis use is warranted.

Type: Article
Title: Use of common analgesic medications and ovarian cancer survival: results from a pooled analysis in the Ovarian Cancer Association Consortium
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/bjc.2017.68
Publisher version: http://dx.doi.org/10.1038/bjc.2017.68
Language: English
Additional information: © 2017 Cancer Research UK. All rights reserved
Keywords: Science & Technology, Life Sciences & Biomedicine, Oncology, Ovarian Cancer, Aspirin, Nonsteroidal Anti-Inflammatory Drugs, NSAID, Paracetamol, Acetaminophen, Pooled Analysis, Survival, Nonsteroidal Antiinflammatory Drugs, Aspirin, Metaanalysis, Diagnosis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL
URI: https://discovery.ucl.ac.uk/id/eprint/1552440
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