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Belimumab in systemic lupus erythematosus (SLE): evidence-to-date and clinical usefulness

Guerreiro Castro, S; Isenberg, DA; (2017) Belimumab in systemic lupus erythematosus (SLE): evidence-to-date and clinical usefulness. Therapeutic Advances in Musculoskeletal Disease , 9 (3) pp. 75-85. 10.1177/1759720X17690474. Green open access

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Abstract

Systemic lupus erythematosus (SLE) is a complex autoimmune rheumatic disease with multiple presentations, whose management presents many challenges. Many disease modifying or immunosuppressive drugs have been used with limited success, especially in patients with more severe disease activity. Belimumab is the first drug to be approved specifically for the treatment of SLE in more than 50 years. By blocking the B-cell activating factor, it interferes in B-cell differentiation and survival. Here we consider the results of the clinical trials that led to its approval, as well as the post-hoc analyses, follow-up studies and the current trials.

Type: Article
Title: Belimumab in systemic lupus erythematosus (SLE): evidence-to-date and clinical usefulness
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/1759720X17690474
Publisher version: https://doi.org/10.1177/1759720X17690474
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Belimumab, biologic therapy, immunosuppressive agents, systemic lupus erythematosus
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: https://discovery.ucl.ac.uk/id/eprint/1551446
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