Skalska, L;
Beltran-Nebot, M;
Ule, J;
Jenner, RG;
(2017)
Regulatory feedback from nascent RNA to chromatin and transcription.
Nature Reviews Molecular Cell Biology
, 18
(5)
pp. 331-337.
10.1038/nrm.2017.12.
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Abstract
Transcription and chromatin function are regulated by proteins that bind to DNA, nucleosomes or RNA polymerase II, with specific non-coding RNAs (ncRNAs) functioning to modulate their recruitment or activity. Unlike ncRNAs, nascent pre-mRNA was considered to be primarily a passive player in these processes. In this Opinion article, we describe recently identified interactions between nascent pre-mRNAs and regulatory proteins, highlight commonalities between the functions of nascent pre-mRNA and nascent ncRNA, and propose that both types of RNA have an active role in transcription and chromatin regulation.
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