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Moving towards population-based genetic risk prediction for ovarian cancer

Rahman, B; Side, L; Gibbon, S; Meisel, SF; Fraser, L; Gessler, S; Wardle, J; (2017) Moving towards population-based genetic risk prediction for ovarian cancer. BJOG: An International Journal of Obstetrics and Gynaecology , 124 (6) pp. 855-858. 10.1111/1471-0528.14603. Green open access

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Abstract

Ovarian cancer is the fifth most common cancer in UK women, and the leading cause of gynaecological cancer death. Five-year survival rates, of around 40%, have shown little improvement despite recent advances in cancer treatment. Mutations in the cancer susceptibility genes BRCA1 and BRCA2 confer lifetime risks of breast and ovarian cancer of up to 80% and 40% respectively. The traditional approach of using cancer family history to select patients for genetic testing is being challenged; up to 44% of BRCA mutation carriers do not have a significant family history. Recent research has shown that offering BRCA testing to all women with high grade non-mucinous ovarian cancer is an effective approach to identifying more BRCA carriers. Furthermore, there is an opportunity to prevent ovarian cancer if women at increased risk can be identified before developing the disease. This article is protected by copyright. All rights reserved.

Type: Article
Title: Moving towards population-based genetic risk prediction for ovarian cancer
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/1471-0528.14603
Publisher version: http://dx.doi.org/10.1111/1471-0528.14603
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst for Women's Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst for Women's Health > Women's Cancer
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > UCL SLASH
UCL > Provost and Vice Provost Offices > UCL SLASH > Faculty of SandHS > Dept of Anthropology
URI: https://discovery.ucl.ac.uk/id/eprint/1543076
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