Irtan, S;
Ehrlich, PF;
Pritchard-Jones, K;
(2016)
Wilms tumor: "State-of-the-art" update, 2016.
Seminars in Pediatric Surgery
, 25
(5)
pp. 250-256.
10.1053/j.sempedsurg.2016.09.003.
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Abstract
Despite an impressive increase in survival rate over the past decades, there is still a need to improve the survival of specific subgroups of Wilms tumor (anaplastic, metastatic, and bilateral) and to decrease the late effects of treatment in terms of renal function and heart toxicity. We aim to explore new areas of improvement, from diagnosis to treatment: in the field of radiology the increased use of MRI and exploration of its diffusion-weighted imaging capabilities to predict WT histology at diagnosis and for preoperative assessment; in biology the emergence of new biomarkers that could be integrated into the decision-making process; and surgical techniques with more accurate indication of nephron-sparing surgery that is no longer reserved for bilateral WT and the minimally invasive approach. The long-term outcome of patients with WT should thus be a strong indicator of the improvement in adapting and personalizing the treatment to each individual.
| Type: | Article |
|---|---|
| Title: | Wilms tumor: "State-of-the-art" update, 2016 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1053/j.sempedsurg.2016.09.003 |
| Publisher version: | http://doi.org/10.1053/j.sempedsurg.2016.09.003 |
| Language: | English |
| Additional information: | © 2016 Elsevier Inc. All rights reserved. This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Pediatrics, Surgery, Wilms tumor, Biology, MRI, Minimally invasive surgery, NSS, CHILDRENS ONCOLOGY GROUP, STAGE RENAL-DISEASE, APPARENT DIFFUSION-COEFFICIENT, RANDOMIZED CONTROLLED-TRIAL, NEPHRON-SPARING SURGERY, SIOP 2001, PREOPERATIVE CHEMOTHERAPY, SURGICAL COMPLICATIONS, INTERNATIONAL SOCIETY, PULMONARY METASTASES |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1540606 |
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