Vasiliadou, R;
Nasr Esfahani, MM;
Brown, NJ;
Welham, KJ;
(2016)
A Disposable Microfluidic Device with a Screen Printed Electrode for Mimicking Phase II Metabolism.
Sensors
, 16
(9)
, Article 1418. 10.3390/s16091418.
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Abstract
Human metabolism is investigated using several in vitro methods. However, the current methodologies are often expensive, tedious and complicated. Over the last decade, the combination of electrochemistry (EC) with mass spectrometry (MS) has a simpler and a cheaper alternative to mimic the human metabolism. This paper describes the development of a disposable microfluidic device with a screen-printed electrode (SPE) for monitoring phase II GSH reactions. The proposed chip has the potential to be used as a primary screening tool, thus complementing the current in vitro methods.
| Type: | Article |
|---|---|
| Title: | A Disposable Microfluidic Device with a Screen Printed Electrode for Mimicking Phase II Metabolism |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3390/s16091418 |
| Publisher version: | http://doi.org/10.3390/s16091418 |
| Language: | English |
| Additional information: | © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Electrochemistry, mass spectrometry, metabolism, screen-printed electrodes |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1538995 |
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