Wandschneider, B;
Koepp, MJ;
(2016)
Pharmaco fMRI: Determining the functional anatomy of the effects of medication.
NeuroImage: Clinical
, 12
pp. 691-697.
10.1016/j.nicl.2016.10.002.
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Abstract
Functional MRI studies have helped to elucidate underlying mechanisms in complex neurological and neuropsychiatric disorders. Disease processes often involve complex large-scale network interactions, extending beyond the presumed main disease focus. Given both the complexity of the clinical phenotype and the underlying dysfunctional brain circuits, so called pharmaco-fMRI (ph-MRI) studies probe pharmacological effects on functional neuro-anatomy, and can help to determine early treatment response, mechanisms of drug efficacy and side effects, and potentially advance CNS drug development. In this review, we discuss recent ph-MRI research in three major neuropsychiatric and neurological disorders and associated network alterations, namely selective serotonin and noradrenergic reuptake inhibitors in affective disorders and emotional processing circuits; antiepileptic drugs in epilepsy and cognitive networks; and stimulants in attention-deficit/hyperactivity disorder and networks of attention control. We conclude that ph-MRI studies show consistent and reproducible changes on disease relevant networks, and prove sensitive to early pharmacological effects on functional anatomy associated with disease. Further CNS drug research and development would benefit greatly from improved disease phenotyping, or biomarkers, using advanced imaging techniques.
Type: | Article |
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Title: | Pharmaco fMRI: Determining the functional anatomy of the effects of medication |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1016/j.nicl.2016.10.002 |
Publisher version: | http://dx.doi.org/10.1016/j.nicl.2016.10.002 |
Additional information: | © 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
Keywords: | Science & Technology, Life Sciences & Biomedicine, Neuroimaging, Neurosciences & Neurology, Pharmacological, Functional MRI, CNS drug research, Biomarker, TEMPORAL-LOBE EPILEPSY, JUVENILE MYOCLONIC EPILEPSY, DEFAULT MODE NETWORK, ATTENTION-DEFICIT/HYPERACTIVITY DISORDER, COGNITIVE-BEHAVIORAL THERAPY, WORKING-MEMORY NETWORKS, CNS DRUG DEVELOPMENT, LANGUAGE DISTURBANCES, HEALTHY-VOLUNTEERS, TREATMENT RESPONSE |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy |
URI: | https://discovery.ucl.ac.uk/id/eprint/1538616 |
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