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Shifting from tuberculosis control to elimination: Where are we? What are the variables and limitations? Is it achievable?

Centis, R; D'Ambrosio, L; Zumla, A; Migliori, GB; (2016) Shifting from tuberculosis control to elimination: Where are we? What are the variables and limitations? Is it achievable? International Journal of Infectious Diseases 10.1016/j.ijid.2016.11.416. (In press). Green open access

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Abstract

Tuberculosis (TB) is a priority in terms of incidence and mortality, with about 10.4 million new incident cases and 1.8 million deaths in 2015. The End-TB strategy recently launched by the World Health Organization in the context of the post-2015 agenda, aimed to achieve TB elimination, represents an evolution of the previous historical strategies originally aimed to achieve TB control. Globally, the current decline in TB incidence is rather slow at approximately 1,5% per year to reach the TB pre-elimination phase by 2035 (A more aggressive approach based on diagnosis and treatment of latently infected individuals has been proposed in the context of TB elimination to ensure future generations free of TB. We describes 4 scenarios which, combined, describe the TB epidemiology in a given setting: 1) in absence of interventions, 2) with early TB diagnosis and effective treatment, 3) with irregular TB treatment, 4) with TB co-infected by HIV not undergoing anti-retroviral treatment. To achieve TB Elimination, a more concerted action by funders and governments will be required for further investments into TB prevention, detection and treatment.

Type: Article
Title: Shifting from tuberculosis control to elimination: Where are we? What are the variables and limitations? Is it achievable?
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ijid.2016.11.416
Publisher version: http://dx.doi.org/10.1016/j.ijid.2016.11.416
Language: English
Additional information: © 2016 The Author. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: Tuberculosis; Elimination; MDR-TB; LTBI; Strategy
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
URI: https://discovery.ucl.ac.uk/id/eprint/1536748
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