UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Subcortical Source and Modulation of the Narrowband Gamma Oscillation in Mouse Visual Cortex

Saleem, AB; Lien, AD; Krumin, M; Haider, B; Rosón, MR; Ayaz, A; Reinhold, K; ... Harris, KD; + view all (2017) Subcortical Source and Modulation of the Narrowband Gamma Oscillation in Mouse Visual Cortex. Neuron , 93 (2) pp. 315-322. 10.1016/j.neuron.2016.12.028. Green open access

[thumbnail of Saleem_etal_Neuron2017.pdf]
Preview
Text
Saleem_etal_Neuron2017.pdf - Published version

Download (1MB) | Preview

Abstract

Primary visual cortex exhibits two types of gamma rhythm: broadband activity in the 30-90 Hz range and a narrowband oscillation seen in mice at frequencies close to 60 Hz. We investigated the sources of the narrowband gamma oscillation, the factors modulating its strength, and its relationship to broadband gamma activity. Narrowband and broadband gamma power were uncorrelated. Increasing visual contrast had opposite effects on the two rhythms: it increased broadband activity, but suppressed the narrowband oscillation. The narrowband oscillation was strongest in layer 4 and was mediated primarily by excitatory currents entrained by the synchronous, rhythmic firing of neurons in the lateral geniculate nucleus (LGN). The power and peak frequency of the narrowband gamma oscillation increased with light intensity. Silencing the cortex optogenetically did not abolish the narrowband oscillation in either LGN firing or cortical excitatory currents, suggesting that this oscillation reflects unidirectional flow of signals from thalamus to cortex.

Type: Article
Title: Subcortical Source and Modulation of the Narrowband Gamma Oscillation in Mouse Visual Cortex
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neuron.2016.12.028
Publisher version: http://dx.doi.org/10.1016/j.neuron.2016.12.028
Language: English
Additional information: © 2017 The Authors. Published by Elsevier Inc. This is an open access article under the Creative Commons Attribution 4.0 International (CC BY 4.0) license (http://creativecommons.org/licenses/by/4.0/)
Keywords: Gamma, lateral geniculate nucleus, mouse vision, neural circuits, primary visual cortex, thalamus
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Experimental Psychology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/1536433
Downloads since deposit
110Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item