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Coordinated shift of olfactory amino acid responses and V2R expression to an amphibian water nose during metamorphosis

Syed, AS; Sansone, A; Hassenklöver, T; Manzini, I; Korsching, SI; (2016) Coordinated shift of olfactory amino acid responses and V2R expression to an amphibian water nose during metamorphosis. Cellular and Molecular Life Sciences , 74 (9) pp. 1711-1719. 10.1007/s00018-016-2437-1. Green open access

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Abstract

All olfactory receptors identified in teleost fish are expressed in a single sensory surface, whereas mammalian olfactory receptor gene families segregate into different olfactory organs, chief among them the main olfactory epithelium expressing ORs and TAARs, and the vomeronasal organ expressing V1Rs and V2Rs. A transitional stage is embodied by amphibians, with their vomeronasal organ expressing more 'modern', later diverging V2Rs, whereas more 'ancient', earlier diverging V2Rs are expressed in the main olfactory epithelium. During metamorphosis, the main olfactory epithelium of Xenopus tadpoles transforms into an air-filled cavity (principal cavity, air nose), whereas a newly formed cavity (middle cavity) takes over the function of a water nose. We report here that larval expression of ancient V2Rs is gradually lost from the main olfactory epithelium as it transforms into the air nose. Concomitantly, ancient v2r gene expression begins to appear in the basal layers of the newly forming water nose. We observe the same transition for responses to amino acid odorants, consistent with the hypothesis that amino acid responses may be mediated by V2R receptors.

Type: Article
Title: Coordinated shift of olfactory amino acid responses and V2R expression to an amphibian water nose during metamorphosis
Location: Switzerland
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s00018-016-2437-1
Publisher version: http://doi.org/10.1007/s00018-016-2437-1
Language: English
Additional information: The final publication is available at Springer via http://dx.doi.org/ 10.1007/s00018-016-2437-1.
Keywords: Amino acid odorants, Calcium imaging, Evolution, Metamorphosis, Olfactory receptors, V2R family
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/1535668
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