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The incidence of myelodysplastic syndromes in Western Greece is increasing.

Avgerinou, C; Alamanos, Y; Zikos, P; Lampropoulou, P; Melachrinou, M; Labropoulou, V; Tavernarakis, I; ... Symeonidis, A; + view all (2013) The incidence of myelodysplastic syndromes in Western Greece is increasing. Ann Hematol , 92 (7) pp. 877-887. 10.1007/s00277-013-1712-6. Green open access

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Abstract

Descriptive epidemiology of the myelodysplastic syndromes (MDS) is always interesting and may reveal time-dependent and geographical variations, as well as occupational exposure. Epidemiological data in Greece are not available by now. We have collected and analyzed medical records of all patients with a documented diagnosis of MDS, performed by an expert hematologist and/or hematopathologist, in the geographical area of Western Greece, during the 20-year period, defined between 1990 and 2009. We have then calculated and described demographic and clinical features of the diagnosed MDS patient population, and assessed the incidence and prevalence rates of MDS in Western Greece, during the above-mentioned period. A total of 855 patients with newly diagnosed MDS have been identified. Refractory anemia was the most common subtype in both FAB and WHO classification systems and in both genders. Del-5q and RARS were more commonly encountered among females, and the dysplastic subtype of chronic myelomonocytic leukemia among males. Trisomy 8 was the most common single cytogenetic abnormality. The crude mean annual incidence rate of MDS was 6.0 per 100,000 inhabitants aged ≥15 years old (all subtypes according to FAB), and it was 4.8 per 100,000 when CMML and RAEB-T were excluded. Crude incidence rate was higher in rural than in urban areas, but this finding was not confirmed after age standardization. Age-standardized mean annual incidence rate in men was 7.9/100,000 and in women 3.4/100,000. A continuously increasing incidence rate of MDS has been observed throughout the study period.

Type: Article
Title: The incidence of myelodysplastic syndromes in Western Greece is increasing.
Location: Germany
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s00277-013-1712-6
Publisher version: http://dx.doi.org/10.1007/s00277-013-1712-6
Language: English
Additional information: © The Author(s) 2013. This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
Keywords: Adolescent, Adult, Aged, Aged, 80 and over, Aneuploidy, Chromosome Deletion, Chromosomes, Human, Pair 5, Chromosomes, Human, Pair 8, Disease Progression, Female, Greece, Humans, Incidence, Leukemia, Myelomonocytic, Chronic, Male, Middle Aged, Morbidity, Myelodysplastic Syndromes, Occupations, Prevalence, Prognosis, Rural Population, Sex Distribution, Trisomy, Urban Population, Young Adult
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Primary Care and Population Health
URI: https://discovery.ucl.ac.uk/id/eprint/1535522
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