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Placental Image Analysis using Coupled Diffusion-Weighted and Multi-Echo T2 MRI and a Multi-Compartment Model

Melbourne, A; Pratt, R; Owen, D; Sokloska, M; Bainbridge, A; Atkinson, D; Kendall, G; ... Ourselin, S; + view all (2016) Placental Image Analysis using Coupled Diffusion-Weighted and Multi-Echo T2 MRI and a Multi-Compartment Model. In: Proceedings of PIPPI 2016. MICCAI Workshop on Perinatal, Preterm and Paediatric Image analysis (PIPPI): Athens, Greece. Green open access

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Abstract

Current popular methods of ow and uid measurement are confounded by the interaction of relaxation and perfusion characteristics which are rarely simultaneously considered. To address this shortcoming we propose a new multi-compartment model for the tissue signal in MRI and apply this to placenta imaging data. Motivated by the different flow characteristics across the placenta, a three compartment model comprising fast and slowly circulating uid pools and a tissue pool is fitted to overlapping multi-echo T2 relaxometry and an intra-voxel incoherent motion diffusion acquisition with low b-values. The new model is supported by a modified image acquisition to enable successful model fitting, but this acquisition is clinically practical; we implemented the acquisition on a standard 1.5T clinical system with acquisition taking less than 20 minutes with 26 slices. This is particularly important for placenta image acquisition. We test this combined acquisition and model-fitting routine on simulated data and show parametric maps for a placenta dataset.

Type: Proceedings paper
Title: Placental Image Analysis using Coupled Diffusion-Weighted and Multi-Echo T2 MRI and a Multi-Compartment Model
Event: PIPPI 2016: MICCAI Workshop on Perinatal, Preterm and Paediatric Image analysis
Location: Athens, Greece
Dates: 21 October 2016 - 21 October 2016
Open access status: An open access version is available from UCL Discovery
Publisher version: http://pippi.cs.ucl.ac.uk/proceedings.html
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Metabolism and Experi Therapeutics
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Maternal and Fetal Medicine
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1534652
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