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The topographical distribution of epileptic spikes in juvenile myoclonic epilepsy with and without photosensitivity.

Bauer, PR; Gorgels, K; Spetgens, W; van Klink, NE; Leijten, FS; Sander, JW; Visser, GH; (2017) The topographical distribution of epileptic spikes in juvenile myoclonic epilepsy with and without photosensitivity. Clin Neurophysiol , 128 (1) pp. 176-182. 10.1016/j.clinph.2016.10.098. Green open access

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Abstract

OBJECTIVE: Up to 30% of people with juvenile myoclonic epilepsy (JME) have photoparoxysmal responses (PPR). Recent studies report on structural and pathophysiological differences between people with JME with (JME+PPR) and without PPR (JME-PPR). We investigated whether electrophysiological features outside photic stimulation differ between these subtypes. METHODS: We analysed EEG recordings of people with JME at a tertiary epilepsy centre and an academic hospital. Photosensitivity was assessed in a drug-naïve condition. We compared the occurrence and involvement of posterior electrodes for focal abnormalities and generalised spike-wave activity in the EEG outside photic stimulation between JME+PPR and JME-PPR. RESULTS: We included EEG recordings of 18 people with JME+PPR and 21 with JME-PPR. People with JME-PPR had less focal abnormalities in the posterior brain regions than people with JME+PPR (19% vs 55%, p<0.05). There was no difference in the distribution of generalised spike-wave activity between people with JME+PPR and JME-PPR. CONCLUSION: This study demonstrates electrophysiological correlates of the previously described structural and physiological differences between JME+PPR and JME-PPR. SIGNIFICANCE: Findings support the hypothesis that posterior interictal EEG abnormalities reflect localised cortical hyperexcitability, which makes patients with JME more sensitive to photic stimuli.

Type: Article
Title: The topographical distribution of epileptic spikes in juvenile myoclonic epilepsy with and without photosensitivity.
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.clinph.2016.10.098
Publisher version: http://dx.doi.org/10.1016/j.clinph.2016.10.098
Language: English
Additional information: © 2016. This manuscript version is published under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International licence (CC BY-NC-ND 4.0). This licence allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licences are available at http://creativecommons.org/licenses/by/4.0. Access may be initially restricted by the publisher.
Keywords: Electroencephalography, Interictal discharges, Intermittent photic stimulation, Juvenile myoclonic epilepsy, Photosensitivity
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
URI: https://discovery.ucl.ac.uk/id/eprint/1533961
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