Howorka, S;
Siwy, Z;
(2016)
Nanopores and Nanochannels: From Gene Sequencing to Genome Mapping.
ACS Nano
, 10
(11)
pp. 9768-9771.
10.1021/acsnano.6b07041.
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Abstract
DNA strands can be analyzed at the single-molecule level by isolating them inside nanoscale holes. The strategy is used for the label-free and portable sequencing with nanopores. Nanochannels can also be applied to map genomes with high resolution, as shown by Jeffet et al. in this issue of ACS Nano. Here, we compare the two strategies in terms of biophysical similarities and differences and describe that both are complementary and can improve the DNA analysis for genomic research and diagnostics.
| Type: | Article |
|---|---|
| Title: | Nanopores and Nanochannels: From Gene Sequencing to Genome Mapping |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1021/acsnano.6b07041 |
| Publisher version: | http://doi.org/10.1021/acsnano.6b07041 |
| Language: | English |
| Additional information: | This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in ACS Nano, copyright © 2017 American Chemical Society after peer review. To access the final edited and published work see http://doi.org/10.1021/acsnano.6b07041 |
| Keywords: | Science & Technology, Physical Sciences, Technology, Chemistry, Multidisciplinary, Chemistry, Physical, Nanoscience & Nanotechnology, Materials Science, Multidisciplinary, Chemistry, High-Resolution, DNA |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1532462 |
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