Gazzina, S;
Premi, E;
Turrone, R;
Acosta-Cabronero, J;
Rizzetti, MC;
Cotelli, MS;
Gasparotti, R;
... Borroni, B; + view all
(2016)
Subcortical matter in the α-synucleinopathies spectrum: an MRI pilot study.
Journal of Neurology
, 263
(8)
pp. 1575-1582.
10.1007/s00415-016-8173-5.
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Abstract
α-Synucleinopathies, such as Parkinson's disease (PD) and dementia with Lewy bodies (DLB), are characterized by α-synuclein accumulation from brainstem structures to the neocortex. PD and DLB are clinically distinguishable, while discrimination between Parkinson Disease Dementia (PDD) and DLB can be subtle and based on the temporal relationship between motor and cognitive symptoms. To explore patterns of subcortical atrophy in PD, PDD and DLB, and assess specific differences between PD and PDD, and between DLB and PDD. 16 PD, 11 PDD and 16 DLB patients were recruited and underwent 1.5 Tesla structural MRI scanning. Segmentation of subcortical structures was performed with a well-validated, fully-automated tool, and volume and shape for each structure were compared between groups. PDD and DLB patients showed global subcortical atrophy compared to PD patients. Greater hippocampal atrophy was the specific trait that distinguished PDD from PD, while greater atrophy of the pallidi discriminated DLB from PDD. Vertex analysis revealed specific shape differences in both structures. Our results suggest that automated, time-sparing, subcortical volumetry may provide diagnostically useful information in α-synucleinopathies. Future studies on larger samples and with iron-sensitive MRI contrasts are needed.
| Type: | Article |
|---|---|
| Title: | Subcortical matter in the α-synucleinopathies spectrum: an MRI pilot study |
| Location: | Germany |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s00415-016-8173-5 |
| Publisher version: | http://doi.org/10.1007/s00415-016-8173-5 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Basal ganglia, FIRST, Lewy body dementia, Parkinson disease, Analysis of Variance, Brain, Chi-Square Distribution, Dementia, Female, Humans, Image Processing, Computer-Assisted, Italy, Lewy Body Disease, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Parkinson Disease, Pilot Projects, Psychiatric Status Rating Scales, Severity of Illness Index, alpha-Synuclein |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1531838 |
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