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An Integrative Tinnitus Model Based on Sensory Precision.

Sedley, W; Friston, KJ; Gander, PE; Kumar, S; Griffiths, TD; (2016) An Integrative Tinnitus Model Based on Sensory Precision. Trends in Neurosciences , 39 (12) pp. 799-812. 10.1016/j.tins.2016.10.004. Green open access

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Abstract

Tinnitus is a common disorder that often complicates hearing loss. Its mechanisms are incompletely understood. Current theories proposing pathophysiology from the ear to the cortex cannot individually - or collectively - explain the range of experimental evidence available. We propose a new framework, based on predictive coding, in which spontaneous activity in the subcortical auditory pathway constitutes a 'tinnitus precursor' which is normally ignored as imprecise evidence against the prevailing percept of 'silence'. Extant models feature as contributory mechanisms acting to increase either the intensity of the precursor or its precision. If precision (i.e., postsynaptic gain) rises sufficiently then tinnitus is perceived. Perpetuation arises through focused attention, which further increases the precision of the precursor, and resetting of the default prediction to expect tinnitus.

Type: Article
Title: An Integrative Tinnitus Model Based on Sensory Precision.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.tins.2016.10.004
Publisher version: http://dx.doi.org/10.1016/j.tins.2016.10.004
Additional information: © 2016 The Author. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: Auditory cortex, precision, predictive coding, tinnitus
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/1530702
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