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Examining the relationship between physical illness and depression: Is there a difference between inflammatory and non inflammatory diseases? A cohort study

Caneo, C; Marston, L; Bellón, JÁ; King, M; (2016) Examining the relationship between physical illness and depression: Is there a difference between inflammatory and non inflammatory diseases? A cohort study. Gen Hosp Psychiatry , 43 pp. 71-77. 10.1016/j.genhosppsych.2016.09.007. Green open access

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Abstract

BACKGROUND: There is evidence that inflammation may play a role in the association between physical illness and depression. Our aim was to compare the impact of chronic medical conditions on incidence of depression and to examine if risk of depression varies in terms of the presence and degree of inflammation. METHODS: This is a secondary analysis conducted within the Spanish sample of the predictD-study. PARTICIPANTS: 5437. PRIMARY OUTCOME: Incident major depression measured with the Composite International Diagnostic Interview. EXPOSURE: Presence of chronic medical conditions recorded by GPs using the International Classification of Primary Care, ICPC-2. All analyses were conducted using multivariable logistic regression to allow adjustment for confounders. RESULTS: The odds of depression are higher in almost all inflammatory than in non-inflammatory illnesses. There is an increasing risk of depression as a consequence of an increasing inflammatory load, with higher odds of depression in the autoimmune group than in the cardio-metabolic group, while both had higher odds of depression than the non-inflammatory groups. CONCLUSIONS: Inflammation may be part of the pathway by which chronic physical illness leads to depression. Future studies should examine the role of inflammation in the prevention and management of depression.

Type: Article
Title: Examining the relationship between physical illness and depression: Is there a difference between inflammatory and non inflammatory diseases? A cohort study
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.genhosppsych.2016.09.007
Publisher version: http://dx.doi.org/10.1016/j.genhosppsych.2016.09.0...
Language: English
Additional information: © 2016. This manuscript version is published under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International licence (CC BY-NC-ND 4.0). This licence allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licences are available at http://creativecommons.org/licenses/by/4.0. Access may be initially restricted by the publisher.
Keywords: Chronic medical illnesses, Cohort study, Depression, Inflammation, Inflammatory disorders, Major depressive disorder
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Primary Care and Population Health
URI: https://discovery.ucl.ac.uk/id/eprint/1527009
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