O'Callaghan, J;
Holmes, H;
Powell, N;
Ismail, O;
Colgan, N;
Wells, J;
Siow, B;
... Shmueli, K; + view all
(2015)
Gadolinium-Enhanced Magnetic Susceptibility Contrast Is Reduced in the Corpus Callosum of a Mouse Model of Tauopathy.
In:
Proc. Intl. Soc. Mag. Reson. Med. 23 (2015).
ISMRM
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Abstract
Alterations to white matter have been implicated in a number of neurodegenerative diseases. In this work we investigate the sensitivity of MRI magnetic susceptibility mapping to these changes using a mouse model of Tauopathy. A non-rigid registration of contrast enhanced, high resolution ex vivo mouse brain images is used to transform susceptibility maps into a common space and a voxel-wise group comparison is performed. Significant differences were observed that may indicate disruption to the tissue of the corpus callosum.
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