Saignavongs, M;
Ciumas, C;
Petton, M;
Bouet, R;
Boulogne, S;
Rheims, S;
Carmichael, DW;
... Ryvlin, P; + view all
(2017)
Neural Activity Elicited by a Cognitive Task can be Detected in Single-Trials with Simultaneous Intracerebral EEG-fMRI Recordings.
International Journal of Neural Systems
, 27
(1)
, Article 1750001. 10.1142/S0129065717500010.
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Abstract
Recent studies have shown that it is feasible to record simultaneously intracerebral EEG (icEEG) and functional magnetic resonance imaging (fMRI) in patients with epilepsy. While it has mainly been used to explore the hemodynamic changes associated with epileptic spikes, this approach could also provide new insight into human cognition. However, the first step is to ensure that cognitive EEG components, that have lower amplitudes than epileptic spikes, can be appropriately detected under fMRI. We compared the high frequency activities (HFA, 50–150Hz) elicited by a reading task in icEEG-only and subsequent icEEG-fMRI in the same patients (n=3n=3), implanted with depth electrodes. Comparable responses were obtained, with 71% of the recording sites that responded during the icEEG-only session also responding during the icEEG-fMRI session. For all the remaining sites, nearby clusters (distant of 7mm or less) also demonstrated significant HFA increase during the icEEG-fMRI session. Significant HFA increases were also observable at the single-trial level in icEEG-fMRI recordings. Our results show that low-amplitude icEEG signal components such as cognitive-induced HFAs can be reliably recorded with simultaneous fMRI. This paves the way for the use of icEEG-fMRI to address various fundamental and clinical issues, notably the identification of the neural correlates of the BOLD signal.
| Type: | Article |
|---|---|
| Title: | Neural Activity Elicited by a Cognitive Task can be Detected in Single-Trials with Simultaneous Intracerebral EEG-fMRI Recordings |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1142/S0129065717500010 |
| Publisher version: | http://dx.doi.org/10.1142/S0129065717500010 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Artificial Intelligence, Computer Science, Intracranial EEG, simultaneous icEEG-fMRI, high frequency activity, gamma activity, data quality, SIMULTANEOUS INTRACRANIAL EEG, HIGH-FREQUENCY OSCILLATIONS, GAMMA-OSCILLATIONS, EPILEPTIFORM DISCHARGES, IMAGING-ARTIFACT, 3 T, QUALITY, HUMANS, EPILEPSY, PROTOCOL |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1524790 |
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