Chen, LJ;
Steptoe, A;
Ku, PW;
(2017)
Obesity, Apolipoprotein E ε4, and Difficulties in Activities of Daily Living Among Older Adults: a 6-Year Follow-up Study.
Annals of Behavioral Medicine
, 51
(2)
pp. 251-260.
10.1007/s12160-016-9848-y.
(In press).
Preview |
Text
Chen_Obesity, Apolipoprotein.pdf - Accepted Version Download (205kB) | Preview |
Abstract
BACKGROUND: Obesity has been associated with increased physical limitations among older adults, although few studies have adjusted for important covariates. There is limited information about the relationship between apolipoprotein E (APOE) polymorphisms and physical limitations, and the findings have been inconsistent. PURPOSE: This study examined the longitudinal associations of obesity and APOE ε4 with difficulties in activities of daily living (ADLs) over a 6-year follow-up period controlling for multiple covariates. METHODS: Data were analyzed from the Social Environment and Biomarkers of Aging Study (SEBAS) in Taiwan collected in 2000 and 2006, involving a cohort of 639 participants (mean age = 66). Body mass index (BMI) was used to define obesity at a baseline, and the APOE genotype was classified into an APOE ε4 carrier and non-carrier status. The combination of basic and instrumental activities of daily living (ADLs and IADLs) was used to define impaired ADLs. RESULTS: APOE ε4 carriers had greater difficulties in combined ADLs (incident rate ratio; IRR = 1.87, 95 % CI = 1.40-2.51) than non-carriers. Obese but not overweight adults had greater difficulties in activities of daily living (IRR = 1.59, 95 % CI = 1.20-2.10) compared with the normal/underweight group. Obese older adults without APOE ε4 had greater subsequent difficulties in ADLs than non-obese non-carriers. Among APOE ε4 carriers, obesity was not a significant risk factor for the development of impaired ADLs in older adults, indicating an interaction between genotype and obesity. CONCLUSIONS: The interaction between genotype and obesity phenotype adds new information about the determinants of physical impairment.
| Type: | Article |
|---|---|
| Title: | Obesity, Apolipoprotein E ε4, and Difficulties in Activities of Daily Living Among Older Adults: a 6-Year Follow-up Study |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s12160-016-9848-y |
| Publisher version: | http://dx.doi.org/10.1007/s12160-016-9848-y |
| Language: | English |
| Additional information: | Copyright © The Society of Behavioral Medicine 2016. The final publication is available at Springer via http://dx.doi.org/10.1007/s12160-016-9848-y |
| Keywords: | Mobility, Overweight, Physical disability, Physical function, Weight status |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Behavioural Science and Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1524721 |
Archive Staff Only
 |
View Item |
