Fonseca, M;
Saratoon, T;
Zeqiri, B;
Beard, P;
Cox, B;
(2016)
Sensitivity of quantitative photoacoustic tomography inversion schemes to experimental uncertainty.
In: Oraevsky, AA and Wang, LV, (eds.)
Proceedings of SPIE 9708, Photons Plus Ultrasound: Imaging and Sensing.
Society of Photo-Optical Instrumentation Engineers (SPIE): San Francisco, California, United States.
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Abstract
The ability to accurately quantify chromophore concentration from photoacoustic images would have a major impact on pre-clinical and clinical imaging. Recent years have seen significant advances in the theoretical understanding of quantitative photoacoustic imaging and in the development of model-based inversion strategies that overcome issues such as non-uniqueness and non-linearity. Nevertheless, their full in vivo implementation has not successfully been achieved, partially because experimental uncertainties complicate the transition. In this study, a sensitivity analysis is performed to assess the impact on accuracy of having uncertainty in critical experimental parameters such as scattering, beam diameter, beam position and calibration factor. This study was performed using two virtual phantoms, at one illumination and four optical wavelengths. The model-based inversion was applied in 3 variants - one just inverting for chromophores and two others further inverting for either a scaling factor or the scatterer concentration. The performance of these model-based inversions is also compared to linear unmixing strategies - with and without fluence correction. The results show that experimental uncertainties in a priori fixed parameters - especially calibration factor and scatterer concentration - significantly affect accuracy of model-based inversions and therefore measures to ameliorate this uncertainty should be considered. Including a scaling parameter in the inversion appears to improve quantification estimates. Furthermore, even with realistic levels of experimental uncertainty in model-based input parameters, they outperform linear unmixing approaches. If parameter uncertainty is large and has significant impact on accuracy, the parameter can be included as an unknown in model-based schemes.
| Type: | Proceedings paper |
|---|---|
| Title: | Sensitivity of quantitative photoacoustic tomography inversion schemes to experimental uncertainty |
| Event: | Conference on Photons Plus Ultrasound - Imaging and Sensing 2016 |
| Location: | San Francisco, CA |
| Dates: | 14 February 2016 - 17 February 2016 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1117/12.2210916 |
| Publisher version: | https://doi.org/10.1117/12.2210916 |
| Language: | English |
| Additional information: | Copyright © 2016 Society of Photo Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. |
| Keywords: | quantitative photoacoustic imaging, virtual phantom studies, model-based inversion, unmixing strategies, sources of uncertainty, accuracy |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1522553 |
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