Schmidt, A;
Antoniades, M;
Allen, P;
Egerton, A;
Chaddock, CA;
Borgwardt, S;
Fusar-Poli, P;
... McGuire, P; + view all
(2017)
Longitudinal alterations in motivational salience processing in ultra-high-risk subjects for psychosis.
Psychological Medicine
, 47
(2)
pp. 243-254.
10.1017/S0033291716002439.
Preview |
Text
Roiser_longitudinal_alterations_in_motivational_salience_processing_in_ultrahighrisk_subjects_for_psychosis.pdf - Published Version Download (399kB) | Preview |
Abstract
BACKGROUND: Impairments in the attribution of salience are thought to be fundamental to the development of psychotic symptoms and the onset of psychotic disorders. The aim of the present study was to explore longitudinal alterations in salience processing in ultra-high-risk subjects for psychosis. METHOD: A total of 23 ultra-high-risk subjects and 13 healthy controls underwent functional magnetic resonance imaging at two time points (mean interval of 17 months) while performing the Salience Attribution Test to assess neural responses to task-relevant (adaptive salience) and task-irrelevant (aberrant salience) stimulus features. RESULTS: At presentation, high-risk subjects were less likely than controls to attribute salience to relevant features, and more likely to attribute salience to irrelevant stimulus features. These behavioural differences were no longer evident at follow-up. When attributing salience to relevant cue features, ultra-high-risk subjects showed less activation than controls in the ventral striatum at both baseline and follow-up. Within the high-risk sample, amelioration of abnormal beliefs over the follow-up period was correlated with an increase in right ventral striatum activation during the attribution of salience to relevant cue features. CONCLUSIONS: These findings confirm that salience processing is perturbed in ultra-high-risk subjects for psychosis, that this is linked to alterations in ventral striatum function, and that clinical outcomes are related to longitudinal changes in ventral striatum function during salience processing.
| Type: | Article |
|---|---|
| Title: | Longitudinal alterations in motivational salience processing in ultra-high-risk subjects for psychosis |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1017/S0033291716002439 |
| Publisher version: | http://dx.doi.org/10.1017/S0033291716002439 |
| Language: | English |
| Additional information: | Copyright © Cambridge University Press 2016. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Clinical high risk for psychosis, longitudinal studies, motivational salience, psychosis, ventral striatum |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Institute of Cognitive Neuroscience |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1522282 |
Archive Staff Only
 |
View Item |
