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The interaction between systemic inflammation and psychosocial stress in the association with cardiac troponin elevation: A new approach to risk assessment and disease prevention

Lazzarino, AI; Hamer, M; Gaze, D; Collinson, P; Rumley, A; Lowe, G; Steptoe, A; (2016) The interaction between systemic inflammation and psychosocial stress in the association with cardiac troponin elevation: A new approach to risk assessment and disease prevention. Preventive Medicine , 93 pp. 46-52. 10.1016/j.ypmed.2016.09.018. Green open access

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Abstract

We have previously shown that there is a complex and dynamic biological interaction between acute mental stress and acute release of inflammatory factors into the blood stream in relation to heart disease. We now hypothesize that the presence of chronic psychosocial stress may modify the weight of single test results for inflammation as a predictor of heart disease. Using a cross-sectional design, 500 participants free from heart disease drawn from the Whitehall II study in UK in 2006–2008 were tested for plasma fibrinogen as an inflammatory factor, financial strain as a marker of chronic psychosocial stress, coronary calcification measured using computed tomography, and for plasma high-sensitivity cardiac troponin T (HS-CTnT) as a marker of cardiac risk. Fibrinogen concentration levels above the average were associated with a 5-fold increase in the odds of HS-CTnT positivity only among individuals with financial strain (N = 208, OR = 4.73, 95%CI = 1.67 to 13.40, P = 0.003). Fibrinogen was in fact not associated with HS-CTnT positivity in people without financial strain despite the larger size of that subsample (n = 292, OR = 0.84, 95%CI = 0.42 to 1.67, P = 0.622). A test for interaction on the full sample (N = 500) showed a P value of 0.010 after adjusting for a range of demographics, health behaviours, traditional cardiovascular risk factors, psychosocial stressors, inflammatory cytokines, and coronary calcification. In conclusion, elevated fibrinogen seems to be cardio-toxic only when is combined with financial strain. Chronic psychosocial stress may modify the meaning that we should give to single test results for inflammation. Further research is needed to confirm our results.

Type: Article
Title: The interaction between systemic inflammation and psychosocial stress in the association with cardiac troponin elevation: A new approach to risk assessment and disease prevention
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ypmed.2016.09.018
Publisher version: http://dx.doi.org/10.1016/j.ypmed.2016.09.018
Language: English
Additional information: © 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Science & Technology, Life Sciences & Biomedicine, Public, Environmental & Occupational Health, Medicine, General & Internal, General & Internal Medicine, Allostasis, Atherosclerosis, Cardiovascular diseases, Fibrinogen, Neuroendocrinology, Psychological stress, Socioeconomic factors, Troponin T, CORONARY-HEART-DISEASE, C-REACTIVE PROTEIN, CARDIOVASCULAR-DISEASE, MENTAL STRESS, SOCIOECONOMIC-STATUS, PSYCHOLOGICAL DISTRESS, ARTERY CALCIFICATION, CORTISOL RESPONSES, PLASMA-FIBRINOGEN, SENSITIVE ASSAY
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Behavioural Science and Health
URI: https://discovery.ucl.ac.uk/id/eprint/1520044
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