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Directional cell movements downstream of Gbx2 and Otx2 control the assembly of sensory placodes

Steventon, B; Mayor, R; Streit, A; (2016) Directional cell movements downstream of Gbx2 and Otx2 control the assembly of sensory placodes. Biology Open , 5 (11) pp. 1620-1624. 10.1242/bio.020966. Green open access

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Abstract

Cranial placodes contribute to sensory structures including the inner ear, the lens and olfactory epithelium and the neurons of the cranial sensory ganglia. At neurula stages, placode precursors are interspersed in the ectoderm surrounding the anterior neural plate before segregating into distinct placodes by as yet unknown mechanisms. Here, we perform live imaging to follow placode progenitors as they aggregate to form the lens and otic placodes. We find that while placode progenitors move with the same speed as their non-placodal neighbours, they exhibit increased persistence and directionality and these properties are required to assemble morphological placodes. Furthermore, we demonstrate that these factors are components of the transcriptional networks that coordinate placode cell behaviour including their directional movements. Together with previous work, our results support a dual role for Otx and Gbx transcription factors in both the early patterning of the neural plate border and the later segregation of its derivatives into distinct placodes.

Type: Article
Title: Directional cell movements downstream of Gbx2 and Otx2 control the assembly of sensory placodes
Open access status: An open access version is available from UCL Discovery
DOI: 10.1242/bio.020966
Publisher version: http://dx.doi.org/10.1242/bio.020966
Language: English
Additional information: © 2016. Published by The Company of Biologists Ltd http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
Keywords: Science & Technology, Life Sciences & Biomedicine, Biology, Life Sciences & Biomedicine - Other Topics, Cell migration, Lens, Live imaging, Morphogenesis, Otic, Peripheral nervous system, CRANIAL PLACODES, XENOPUS-LAEVIS, EXPRESSION, DIFFERENTIATION, SEGREGATION, PRECURSORS, INDUCTION, EMBRYO, LENS
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/1519971
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